Stem-loop hsa-mir-32

Accession

MI0000090

Symbol

HGNC: MIR32

Description

Homo sapiens hsa-mir-32 precursor miRNA mir-32

Gene
family

RF00666; mir-32

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR32 is a microRNA that has been observed to be upregulated in thyroid cancer compared to benign thyroid tumors, indicating a potential role in the pathology of papillary thyroid carcinoma (PTC), although its functional implications in PTC remain unclear [PMC4315163]. Research has shown that MIR32 can directly inhibit the RNA virus, primate foamy retrovirus type 1, and degrade the coding region of influenza PB1 [PMC7833564]. MIR32, along with miR214 and miR98, has been suggested as a potential therapeutic agent for the suppression of Tmprss2, which is considered a critical drug target [PMC7833564]. It is also listed among the top 40 differential genes in a study that may be relevant to its role in disease processes or as biomarkers [PMC9730279]. Experimental studies have utilized MIR32 mimics and antagomirs to investigate its effects by transfecting them into 293 T cells [PMC6967090], and its expression has been measured using real-time PCR assays alongside other microRNAs [PMC3424561]. Changes in the abundance of MIR32 have also been observed in knockout mice studies, which may contribute to understanding its biological functions [PMC10001410].

Literature search

103 open access papers mention hsa-mir-32
(578 sentences)

Sequence

74946 reads, 639 reads per million, 124 experiments

ggagaUAUUGCACAUUACUAAGUUGCAuguugucacggccucaaugCAAUUUAGUGUGUGUGAUAUUUuc
(((((((((((((((.(((((((((((((..((....))..).)))))))))))))))))))))))))))

Structure

               U            - uu  c 
ggagaUAUUGCACAU ACUAAGUUGCAu g  gu a
||||||||||||||| |||||||||||| |  ||  
cuUUUAUAGUGUGUG UGAUUUAACgua c  cg c
               -            a uc  g 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr9: 109046229-109046298 [-]

Disease association

hsa-mir-32 is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-32 is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-32 is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-32-5p

• Accession: MIMAT0000090
• Description: Homo sapiens hsa-miR-32-5p mature miRNA
• Sequence: 6 - UAUUGCACAUUACUAAGUUGCA - 27
• Evidence: experimental ; cloned [1-2], Northern [1]

Mature hsa-miR-32-3p

• Accession: MIMAT0004505
• Description: Homo sapiens hsa-miR-32-3p mature miRNA
• Sequence: 47 - CAAUUUAGUGUGUGUGAUAUUU - 68
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 11679670
   Identification of novel genes coding for small expressed RNAs
   "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
   "Science (2001) 294:853-858


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414