Stem-loop hsa-mir-32

Accession

MI0000090

Symbol

HGNC: MIR32

Description

Homo sapiens hsa-mir-32 precursor miRNA mir-32

Gene
family

RF00666; mir-32

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR32 is a microRNA that has been found to be upregulated in thyroid cancer compared to benign thyroid tumors in a microarray study [PMC4315163]. However, the functional implications of MIR32 in papillary thyroid carcinoma (PTC) are still unknown [PMC4315163]. Studies have shown that MIR32 can directly inhibit the RNA virus primate foamy retrovirus type 1, which is comparable to HIV1, at the protein level [PMC7833564]. Additionally, MIR32 has been found to have a supplementary degradative function in the coding region for influenza PB1 [PMC7833564]. In the context of Tmprss2 as a critical drug target, it has been suggested that MIR32 could be employed as a potential therapeutic for specific suppression of Tmprss2 [PMC7833564]. Differential gene analysis identified MIR32 as one of the top 40 differential genes in thyroid cancer [PMC9730279]. In experimental studies, MIR32 mimics and antagomirs were transfected into 293 T cells to investigate their effects on PIKfyve-3' UTR Wt and PIKfyve-3' UTR Mut expression levels [PMC6967090]. Real-time PCR assays were used to assess the expression levels of various miRNAs including MIR32 in different experimental conditions [PMC3424561] and it was found that miRNAs such as miR140, miR141, and miR184 showed decreased abundance while miRNAs such as miR150 and miR146 showed increased abundance in knockout mice compared to wild-type mice [PMC10001410].

Literature search

103 open access papers mention hsa-mir-32
(578 sentences)

Sequence

74946 reads, 639 reads per million, 124 experiments

ggagaUAUUGCACAUUACUAAGUUGCAuguugucacggccucaaugCAAUUUAGUGUGUGUGAUAUUUuc
(((((((((((((((.(((((((((((((..((....))..).)))))))))))))))))))))))))))

Structure

               U            - uu  c 
ggagaUAUUGCACAU ACUAAGUUGCAu g  gu a
||||||||||||||| |||||||||||| |  ||  
cuUUUAUAGUGUGUG UGAUUUAACgua c  cg c
               -            a uc  g 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr9: 109046229-109046298 [-]

Disease association

hsa-mir-32 is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-32 is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-32 is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-32-5p

• Accession: MIMAT0000090
• Description: Homo sapiens hsa-miR-32-5p mature miRNA
• Sequence: 6 - UAUUGCACAUUACUAAGUUGCA - 27
• Evidence: experimental ; cloned [1-2], Northern [1]

Mature hsa-miR-32-3p

• Accession: MIMAT0004505
• Description: Homo sapiens hsa-miR-32-3p mature miRNA
• Sequence: 47 - CAAUUUAGUGUGUGUGAUAUUU - 68
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 11679670
   Identification of novel genes coding for small expressed RNAs
   "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
   "Science (2001) 294:853-858


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414