Stem-loop hsa-mir-33a

Accession

MI0000091

Symbol

HGNC: MIR33A

Description

Homo sapiens hsa-mir-33a precursor miRNA

Gene family

MIPF0000070; mir-33

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

Hsa-mir-33a is a microRNA that has been found to play a role in various types of cancer, including glioblastoma, hepatocellular carcinoma (HCC), prostate cancer, lung adenocarcinoma, and endometrial cancer [26][27][45][46][PMC9200351][PMC8843861][PMC8615810][PMC9789638][PMC8257864]. It has been shown to regulate the expression of neuropilin-2, inhibiting glioblastoma cell migration [26]. Depletion of hsa-mir-33a is associated with tumorigenesis and poor prognosis in HCC patients [27]. However, there is no evidence in the provided context to support the claim that hsa-mir-33a can interfere with the cisplatin resistance of HCC cells [28]. In liver cancer, miRNAs related to hsa-mir-33a are enriched in fatty acid synthesis and metabolism pathways [PMC8843861]. Hsa-mir-33a has also been found to be dysregulated in HIV patients and may be involved in lipid metabolism [PMC8615810]. In a study on endometrial cancer progression, hsa-mir-33a was identified as a hub gene in ceRNA networks [PMC9200351]. The gene body of SREBF2, including the hsa-mir-33a locus, was found to be hypomethylated and may contribute to the down-regulation of SREBF2 expression [PMC9789638]. Hsa-mir-33a is also involved in the regulation of MAP4K3 expression in gestational diabetes mellitus (GDM) [PMC8257864]. Overall, hsa-mir-33a has been implicated in various biological processes and diseases through its regulation of target genes.

Literature search

157 open access papers mention hsa-mir-33a
(1512 sentences)

Sequence

98359 reads, 793 reads per million, 116 experiments

cugugGUGCAUUGUAGUUGCAUUGCAuguucuggugguacccaugCAAUGUUUCCACAGUGCAUCACag
((((((((((((((.(..((((((((((....(((...)))))))))))))..).))))))))))))))

Structure

              A UU          uucu   g 
cugugGUGCAUUGU G  GCAUUGCAug    ggu  
|||||||||||||| |  ||||||||||    ||| g
gaCACUACGUGACA C  UGUAACguac    cca  
              C UU          ----   u 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr22: 41900944-41901012 [+]

Disease association

hsa-mir-33a is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-33a is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-33a is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-33a-5p

• Accession: MIMAT0000091
• Description: Homo sapiens hsa-miR-33a-5p mature miRNA
• Sequence: 6 - GUGCAUUGUAGUUGCAUUGCA - 26
• Evidence: experimental ; cloned [1-2], Northern [1]

Mature hsa-miR-33a-3p

• Accession: MIMAT0004506
• Description: Homo sapiens hsa-miR-33a-3p mature miRNA
• Sequence: 46 - CAAUGUUUCCACAGUGCAUCAC - 67
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 11679670
   Identification of novel genes coding for small expressed RNAs
   "Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T"
   "Science (2001) 294:853-858


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414