miRBase entry: hsa-mir-129-1

Stem-loop hsa-mir-129-1

HGNC: MIR129-1
Homo sapiens hsa-mir-129-1 precursor miRNA
Gene family
MIPF0000073; mir-129

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR129-1 is a microRNA (miRNA) transcribed from the MIR129-1 gene located on chromosome 7q32 [PMC3576298]. It plays a role in various biological functions, including cell growth regulation, control of cell transition factors, tissue remodeling, immune responses, and inflammatory reactions [PMC6394761]. Recent studies have demonstrated the potential of MIR129-1 in improving liver function and suppressing inflammation and liver fibrosis in alcoholic liver disease and NASH animal models [PMC8138178]. However, there is no direct evidence from Parkinson's disease or Alzheimer's disease genome-wide association studies (GWAS) suggesting that MIR129-1 is a risk gene [PMC9645562]. One Parkinson's disease risk SNP (rs35048651) located upstream from MIR132 may act as a miRNA expression quantitative trait locus (eQTL) [PMC9645562]. In spinal cord injury studies, both MIR129-2 and MIR129-1 were found to be downregulated [PMC6515063]. The expression of MIR129-1 can be measured using TaqMan probes and normalized using the 2−ΔΔCq method [PMC7399878]. In functional studies, cells were transfected with a MIR129-1 mimic to assess its effects on gene expression using luciferase reporter assays [PMC7399878].

Literature search
120 open access papers mention hsa-mir-129-1
(1023 sentences)


58241 reads, 320 reads per million, 99 experiments

    -       C   CU      G   uu cu  c 
ggau CUUUUUG GGU  GGGCUU Cug  c  cu a
|||| ||||||| |||  |||||| |||  |  ||  
ucUA GAAAAAC CCA  CCCGAA gac  g  ga a
    U       C   UU      g   -u au  c 

Annotation confidence High
Do you think this miRNA is real?
This miRNA sequence was predicted based on homology to a verified miRNA cloned from mouse cerebellum [1]. Expression of this miRNA was subsequently verified in a human osteoblast sarcoma cell line [2]. Reference [2] named the human/mouse conserved sequence miR-129b, but subsequent genome searches suggest that the same mature sequence may be expressed from two predicted hairpin precursors in both human (this entry and MIR:MI0000473) and mouse (MIR:MI0000222 and MIR:MI0000585). Landgraf et al. show that the 5' product of mir-129-1 (this entry) is the predominant one, whereas both 5' and 3' products are significantly expressed from mir-129-2 (MIR:MI0000585) [3].

Genome context
chr7: 128207872-128207943 [+]

Disease association
hsa-mir-129-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-129-5p

Accession MIMAT0000242
Description Homo sapiens hsa-miR-129-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-129-1-3p

Accession MIMAT0004548
Description Homo sapiens hsa-miR-129-1-3p mature miRNA
Evidence experimental
cloned [3]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12554859
    New microRNAs from mouse and human
    "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
    "RNA (2003) 9:175-179

  3. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739