Accession
MI0000253
Symbol
HGNC:
MIR148A
Description
Homo sapiens
hsa-mir-148a precursor miRNA mir-148
Gene
family?
family?
RF00248;
mir-148
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR148A is a microRNA (miRNA) that has been studied for its role in the modulation of protein expression, although it has been found to have minimal impact on protein regulation in cell lines [PMC10057657]. This miRNA, along with miR-148b and miR-152, is part of the miR-148/152 family and is capable of recognizing and binding to specific target sites, which can lead to the downregulation of transgenes with engineered target sites [PMC4467430]. While the effects of psychotropics on MIR148A and other miRNAs, as well as on proteins like REST, are considered worth investigating in Huntington's disease models, the context does not establish a direct influence of MIR148A on various biological processes or its effects on other miRNAs and proteins specifically in HD models [PMC3856079]. Additionally, MIR148A has been identified as a potential regulator of DNMT1 expression, which is notably increased in adipocytes from obese individuals [PMC6817687]. Dysregulation of MIR148A expression has also been observed in immune cells from patients with lupus, implicating it in inflammatory dysfunction and conditions such as T cell autoreactivity and cytokine production [PMC7139533].
Literature search
286 open access papers mention hsa-mir-148a
(1815 sentences)
(1815 sentences)
Sequence
2110050
reads,
13144
reads per million, 157 experiments
gaggcAAAGUUCUGAGACACUCCGACUcugaguaugauagaagUCAGUGCACUACAGAACUUUGUcuc
((((((((((((((((.((((..(((((((.......))).))))))))..)).))))))))))))))
((((((((((((((((.((((..(((((((.......))).))))))))..)).))))))))))))))
Structure
- -A CC - ag
gaggcAAAGUUCUG AG CACU GACU cug u
|||||||||||||| || |||| |||| ||| a
cucUGUUUCAAGAC UC GUGA CUga gau u
A AC -- a ag
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr7: 25949919-25949986 [-]
Disease association
hsa-mir-148a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-148a-5p
| Accession | MIMAT0004549 |
| Description | Homo sapiens hsa-miR-148a-5p mature miRNA |
| Sequence | 6 - AAAGUUCUGAGACACUCCGACU - 27 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
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Mature hsa-miR-148a-3p
| Accession | MIMAT0000243 |
| Description | Homo sapiens hsa-miR-148a-3p mature miRNA |
| Sequence | 44 - UCAGUGCACUACAGAACUUUGU - 65 |
| Evidence |
experimental
cloned [1-3], Northern [2] |
| Database links |
|
| Predicted targets |
|
References
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