Stem-loop hsa-mir-148a

Accession

MI0000253

Symbol

HGNC: MIR148A

Description

Homo sapiens hsa-mir-148a precursor miRNA mir-148

Gene
family

RF00248; mir-148

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR148A is a microRNA that has been studied for its role in protein regulation and target identification in cell lines, but it was found to have minimal protein regulation and no identified protein targets [PMC10057657]. The liver detargeting effects of MIR148A are not only due to its binding to target sites, but also because other members of the MIR148/152 family, such as miR-148b and miR-152, can recognize MIR148A target sites and downregulate transgenes [PMC4467430]. The effects of psychotropics on various miRNAs, including MIR148A, as well as on the REST gene, should be studied in Huntington's disease models [PMC3856079]. DNMT1 is a predicted target of MIR148A and its expression is elevated in adipocytes of obese individuals [PMC6817687]. Dysregulated expression of several miRNAs, including MIR148A, has been found in immune cells from patients with lupus and is associated with dysregulated inflammatory function [PMC7139533]. MIR148A is a microRNA that has minimal protein regulation and no identified protein targets in cell lines [PMC10057657]. It can be detargeted by other members of the MIR148/152 family such as miR-148b and miR-152 [PMC4467430]. The effects of psychotropics on various miRNAs including MIR148A should be studied in Huntington's disease models [PMC3856079]. DNMT1 is a predicted target for MIR148A and its expression is elevated in adipocytes of obese individuals [PMC6817687]. Dysregulated expression of several miRNAs including MIR148A has been found in immune cells from patients with lupus associated with dysregulated inflammatory function.

Literature search

286 open access papers mention hsa-mir-148a
(1815 sentences)

Sequence

2110050 reads, 13144 reads per million, 157 experiments

gaggcAAAGUUCUGAGACACUCCGACUcugaguaugauagaagUCAGUGCACUACAGAACUUUGUcuc
((((((((((((((((.((((..(((((((.......))).))))))))..)).))))))))))))))

Structure

              -  -A    CC    -   ag 
gaggcAAAGUUCUG AG  CACU  GACU cug  u
|||||||||||||| ||  ||||  |||| |||  a
cucUGUUUCAAGAC UC  GUGA  CUga gau  u
              A  AC    --    a   ag 

Annotation confidence High

Genome context

chr7: 25949919-25949986 [-]

Disease association

hsa-mir-148a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-148a-5p

• Accession: MIMAT0004549
• Description: Homo sapiens hsa-miR-148a-5p mature miRNA
• Sequence: 6 - AAAGUUCUGAGACACUCCGACU - 27
• Evidence: experimental ; cloned [3]

Mature hsa-miR-148a-3p

• Accession: MIMAT0000243
• Description: Homo sapiens hsa-miR-148a-3p mature miRNA
• Sequence: 44 - UCAGUGCACUACAGAACUUUGU - 65
• Evidence: experimental ; cloned [1-3], Northern [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15978578
   Identification of human fetal liver miRNAs by a novel method
   "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
   "FEBS Lett (2005) 579:3849-3854


3. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739