Stem-loop hsa-mir-139

Accession

MI0000261

Symbol

HGNC: MIR139

Description

Homo sapiens hsa-mir-139 precursor miRNA mir-139

Gene
family

RF00703; mir-139

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR139 is recognized as a microRNA with tumor suppressor activity in acute myeloid leukemia (AML) [PMC8885418]. This microRNA has been linked to specific targets that are believed to mediate its suppressive functions in the context of AML [PMC8885418]. In the plant species cucumber, homologous genes to those targeted by MIR139 in AML have been identified, including CsTCP27, CsTCP25, CsTCP14, and CsTCP12 [PMC7709023]. However, it should be noted that the well-matched coding regions of these cucumber genes suggest they might be potential targets of miR319, not MIR139, which may indicate a typographical error in the original text [PMC7709023]. The identification of these targets is significant as it provides insight into the evolutionary conservation and functional roles of microRNAs across different species [PMC7709023].

Literature search

116 open access papers mention hsa-mir-139
(670 sentences)

Sequence

70532 reads, 547 reads per million, 132 experiments

guguauUCUACAGUGCACGUGUCUCCAGUguggcucggaggcUGGAGACGCGGCCCUGUUGGAGUaac
...((((((((((.((.((((((((((((.(.......).)))))))))))))).))).)))))))..

Structure

gug       -   U  A            g gg 
   uauUCUA CAG GC CGUGUCUCCAGU u  c
   ||||||| ||| || |||||||||||| |  u
   aUGAGGU GUC CG GCGCAGAGGUcg a  c
-ca       U   C  -            g gg 

Annotation confidence High

Comments

The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context

chr11: 72615063-72615130 [-]

Disease association

hsa-mir-139 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-139-5p

• Accession: MIMAT0000250
• Description: Homo sapiens hsa-miR-139-5p mature miRNA
• Sequence: 7 - UCUACAGUGCACGUGUCUCCAGU - 29
• Evidence: experimental ; cloned [2]

Mature hsa-miR-139-3p

• Accession: MIMAT0004552
• Description: Homo sapiens hsa-miR-139-3p mature miRNA
• Sequence: 43 - UGGAGACGCGGCCCUGUUGGAGU - 65
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739