miRBase entry: cel-mir-237

Stem-loop cel-mir-237


Accession
MI0000312
Description
Caenorhabditis elegans cel-mir-237 precursor miRNA mir-237
Gene
family?
RF03920; mir-237

Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?

Cel-mir-237 is a microRNA (miRNA) that has been identified as a potential predictor of radioresistance [PMC4247386]. It has been found that loss of cel-mir-237 is associated with radioresistance [PMC5173455]. Additionally, there is a temporal correlation between cel-mir-237 and jun-1 expression post-γ-irradiation [PMC5173455]. Experimental studies have shown that cel-mir-237 can alter radiation sensitivity and downregulate jun-1 levels, which is important for cellular survival post-γ-irradiation [PMC5173455]. The expression profile of cel-mir-237 is inversely correlated with jun-1 expression [PMC5173455'>PMC5173455'>PMC5173455'>PMC5173455]. Both cel-mir-237 and hsa-miR125b have been found to induce radiation sensitivity by targeting and downregulating JUN [PMC5173455]. It has been predicted that jun1 is a target of cel-mir-237 based on sequence and conservation analysis [PMC5173455]. The loss of cel-mir-237 protects cells from γ-radiation, while overexpression of cel-miR 237 promotes radiosensitivity in C. elegans nematodes [PMC5173455]. The levels of cel-miR 237 significantly decrease in wild-type N2 animals after γ-radiation treatment, suggesting an active downregulation mechanism to promote survival during and after γ-radiation exposure [PMC5173455].

Literature search
5 open access papers mention cel-mir-237
(11 sentences)

Sequence

13091 reads, 394 reads per million, 11 experiments
uucuacauugcguggUCCCUGAGAAUUCUCGAACAGCUucaaaguguucaagCUGUCGAGUUUUGUCAAGGACCaaacaauagaagaucacuugggaac
(((((..(((..((((((.(((.((..(((((.((((((.((....)).)))))))))))..)).))).))))))..))))))))..............

Structure
--------------     ca   cg      C   G  UU     A      c  a 
              uucua  uug  uggUCC UGA AA  CUCGA CAGCUu aa g
              |||||  |||  |||||| ||| ||  ||||| |||||| ||  
              aagau  aac  aCCAGG ACU UU  GAGCU GUCgaa uu u
caaggguucacuag     --   aa      A   G  UU     -      c  g 


Annotation confidence High
Do you think this miRNA is real?
Comments
The sequence is reported to be related to lin-4 [2]. The extents of the dominant mature miRNA species are adjusted here in accordance with a large scale cloning and sequencing study [3].

Genome context
chrX: 8154084-8154182 [+]

Database links

Mature cel-miR-237-5p

Accession MIMAT0000292
Description Caenorhabditis elegans cel-miR-237-5p mature miRNA
Sequence 16 - UCCCUGAGAAUUCUCGAACAGCU - 38
Evidence experimental
cloned [1-3], Northern [1], Illumina [4,6], CLIPseq [5]
Database links
Predicted targets

Mature cel-miR-237-3p

Accession MIMAT0020333
Description Caenorhabditis elegans cel-miR-237-3p mature miRNA
Sequence 53 - CUGUCGAGUUUUGUCAAGGACC - 74
Evidence experimental
Illumina [6]
Database links

References

  1. PubMed ID: 12672692
    The microRNAs of Caenorhabditis elegans
    "Lim LP, Lau NC, Weinstein EG, Abdelhakim A, Yekta S, Rhoades MW, Burge CB, Bartel DP"
    "Genes Dev (2003) 17:991-1008

  2. PubMed ID: 12747828
    MicroRNAs and other tiny endogenous RNAs in C. elegans
    "Ambros V, Lee RC, Lavanway A, Williams PT, Jewell D"
    "Curr Biol (2003) 13:807-818

  3. PubMed ID: 17174894
    Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegans
    "Ruby JG, Jan C, Player C, Axtell MJ, Lee W, Nusbaum C, Ge H, Bartel DP"
    "Cell (2006) 127:1193-1207

  4. PubMed ID: 19460142
    Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegans development
    Kato M, de Lencastre A, Pincus Z, Slack FJ
    Genome Biol (2009) 10:R54

  5. PubMed ID: 20062054
    Comprehensive discovery of endogenous Argonaute binding sites in Caenorhabditis elegans
    "Zisoulis DG, Lovci MT, Wilbert ML, Hutt KR, Liang TY, Pasquinelli AE, Yeo GW"
    "Nat Struct Mol Biol (2010) 17:173-179

  6. PubMed ID: 21307183
    Improved annotation of C. elegans microRNAs by deep sequencing reveals structures associated with processing by Drosha and Dicer
    "Warf MB, Johnson WE, Bass BL"
    "RNA (2011) 17:563-577