Stem-loop mmu-mir-297a-1

Accession

MI0000395

Description

Mus musculus mmu-mir-297a-1 precursor miRNA mir-297

Gene
family

RF04217; mir-297

Literature search

12 open access papers mention mmu-mir-297a-1
(15 sentences)

Sequence

4886 reads, 151 reads per million, 89 experiments

auauguauguauguAUGUAUGUGUGCAUGUGCAUGUgcauguaugcauauugcauguauauauuaugcauacaugu
.....((((((((((((.(((((((((((((.(((((((....)))))))))))))))))))))))))))))))).

Structure

auaug            U             C       u 
     uauguauguAUG AUGUGUGCAUGUG AUGUgca g
     |||||||||||| ||||||||||||| |||||||  
     guacauacguau uauauauguacgu uauacgu u
----u            -             -       a 

Annotation confidence Low

Comments

Houbaviy et al. report that the cloned sequence of miR-297 is found over 20 times in the mouse genomic sequence [1]. This sequence appears to match several low complexity repetitive regions. Confidence in which loci actually express miR-297 is low because of the low complexity nature of the sequence. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context

chr7: 10958437-10958512 [-]

Mature mmu-miR-297a-5p

• Accession: MIMAT0000375
• Description: Mus musculus mmu-miR-297a-5p mature miRNA
• Sequence: 15 - AUGUAUGUGUGCAUGUGCAUGU - 36
• Evidence: experimental ; cloned [1], Illumina [2-3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12919684
   Embryonic stem cell-specific MicroRNAs
   "Houbaviy HB, Murray MF, Sharp PA"
   "Dev Cell (2003) 5:351-358