miRBase entry: hsa-mir-122

Stem-loop hsa-mir-122

Homo sapiens hsa-mir-122 precursor miRNA
Gene family
MIPF0000095; mir-122

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR122 is a liver-specific microRNA that plays a role in various biological processes, including liver metabolism, viral replication, and hepatocellular carcinoma (HCC) development [PMC7352235]. It has been shown that ADAM10 processes surface c-Met and mediates c-Met ecto-domain shedding, and the effects of MIR122 on the release of soluble c-Met were studied [PMC7352235]. MIR122 is involved in the regulation of hepatic gluconeogenesis and lipid metabolism through HNF-4α [PMC4806913]. Reduced MIR122 function leads to promoter methylation and decreased SOCS3 expression, which is not a direct target of MIR122 [PMC3434395]. HAV-RNA replication does not require MIR122 [PMC7165973]. The inhibitory effect of apigenin on HCV replication is possibly explained by decreasing the levels of mature MIR122 through the inhibition of TRBP phosphorylation [PMC5812025]. Incorporating the target sequence for MIR122 in the 3'untranslated region of the E1A gene can reduce virus replication in normal hepatocytes [PMC7281331]. MIR122, miR34a, and miR379 can be used as markers for early detection or monitoring NAFLD development [PMC9738374]. Deprivation of arginine or combination therapy with sorafenib and drugs that enhance MIR122 expression may be useful for managing HCC with reduced MIR122 expression levels [PMC4480756]. The expression levels of molecules including MIR122 were higher or similar to control cells in Vero/MIR122+SRBI+ApoE cells compared to Huh-7.5.1 cells [PMC4916372]. AKT3 absence partially reproduces effects induced by MIR122 expression but is not sufficient to fully reduce tumor size in BCLC9 cells [PMC5342080].

Literature search
562 open access papers mention hsa-mir-122
(3998 sentences)


335022 reads, 3777 reads per million, 69 experiments

c        -      GG       C           ugucu 
 cuuagcag agcugU  AGUGUGA AAUGGUGUUUG     a
 |||||||| ||||||  ||||||| |||||||||||      
 ggaucguc ucgAUA  UCACACU UUACCGCAAac     a
c        a      AA       A           uauca 

Annotation confidence High
Do you think this miRNA is real?
The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context
chr18: 58451074-58451158 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-122
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-122 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-122-5p

Accession MIMAT0000421
Description Homo sapiens hsa-miR-122-5p mature miRNA
Evidence experimental
cloned [2-3], Northern [2]
Database links
Predicted targets

Mature hsa-miR-122-3p

Accession MIMAT0004590
Description Homo sapiens hsa-miR-122-3p mature miRNA
Evidence experimental
cloned [3]


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854

  3. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739