Accession
MI0000443
Symbol
HGNC:
MIR124-1
Description
Homo sapiens
hsa-mir-124-1 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR124-1 is a gene that encodes for a microRNA, which is a small non-coding RNA molecule playing a role in gene regulation [PMC4268894]. Research has identified a positive interaction between the polymorphism rs531564 in MIR124-1 and rs10759 in the RGS4 gene, which is indicated by an interaction entropy of 0.14% [PMC5848672]. This interaction suggests that MIR124-1 may have an influential role in genetic networks and could potentially contribute to disease processes [PMC4268894]. Conversely, the same study found that rs10759 has a negative interaction with rs951436 in RGS4, with an entropy of -0.13%, highlighting the complex interplay between genetic variants within these regions [PMC5848672]. The findings underscore the importance of MIR124-1 within this genomic interval and its potential implications for disease understanding and possibly for therapeutic targeting [PMC4268894; PMC5848672]..
Literature search
429 open access papers mention hsa-mir-124-1
(3767 sentences)
(3767 sentences)
Sequence
97724
reads,
922
reads per million, 64 experiments
aggccucucucucCGUGUUCACAGCGGACCUUGAUuuaaauguccauacaauUAAGGCACGCGGUGAAUGCCAAgaauggggcug
.((((((..(((..((((((((.(((..((((((((.............))))))))..))).))))))))..)))..)))))).
.((((((..(((..((((((((.(((..((((((((.............))))))))..))).))))))))..)))..)))))).
Structure
a uc cC A GA uaaau ggccuc ucu GUGUUCAC GCG CCUUGAUu g |||||| ||| |||||||| ||| |||||||| u ucgggg agA CGUAAGUG CGC GGAAUuaa c g ua AC G AC cauac
Annotation confidence
High
Do you think this miRNA is real?
Comments
miR-124 was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5]. The 5' end of the miRNA may be offset with respect to previous annotations.
Genome context
chr8: 9903388-9903472 [-]
Disease association
hsa-mir-124-1 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-124-5p
| Accession | MIMAT0004591 |
| Description | Homo sapiens hsa-miR-124-5p mature miRNA |
| Sequence | 14 - CGUGUUCACAGCGGACCUUGAU - 35 |
| Evidence |
experimental
cloned [5] |
Mature hsa-miR-124-3p
| Accession | MIMAT0000422 |
| Description | Homo sapiens hsa-miR-124-3p mature miRNA |
| Sequence | 53 - UAAGGCACGCGGUGAAUGCCAA - 74 |
| Evidence |
experimental
cloned [2,4-5] |
| Database links |
|
| Predicted targets |
|
References
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