miRBase entry: hsa-mir-124-1

Stem-loop hsa-mir-124-1

HGNC: MIR124-1
Homo sapiens hsa-mir-124-1 precursor miRNA
Gene family
MIPF0000021; mir-124

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR124-1 is a gene that has been studied for its potential role in disease [PMC5848672]. In a study, a positive interaction effect was found between rs531564 in the MIR124-1 gene and rs10759 in the RGS4 gene, with an interaction entropy of 0.14% [PMC5848672]. Additionally, a negative interaction effect was observed between rs10759 and rs951436 in RGS4, with an interaction entropy of -0.13% [PMC5848672]. These findings suggest that there may be complex interactions between these genetic variants that could influence disease susceptibility or progression [PMC5848672]. Furthermore, MIR124-1 and MIR598 are genes located within the same interval and are also potentially involved in disease [PMC4268894]. These findings highlight the importance of studying genetic interactions and their potential impact on disease development or progression [PMC4268894]. Understanding these interactions could provide valuable insights into the underlying mechanisms of diseases and potentially lead to new therapeutic strategies or interventions [PMC5848672] [PMC4268894].

Literature search
429 open access papers mention hsa-mir-124-1
(3767 sentences)


97724 reads, 922 reads per million, 64 experiments

a      uc   cC        A   GA        uaaau 
 ggccuc  ucu  GUGUUCAC GCG  CCUUGAUu     g
 ||||||  |||  |||||||| |||  ||||||||     u
 ucgggg  agA  CGUAAGUG CGC  GGAAUuaa     c
g      ua   AC        G   AC        cauac 

Annotation confidence High
Do you think this miRNA is real?
miR-124 was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context
chr8: 9903388-9903472 [-]

Disease association
hsa-mir-124-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-124-5p

Accession MIMAT0004591
Description Homo sapiens hsa-miR-124-5p mature miRNA
Evidence experimental
cloned [5]

Mature hsa-miR-124-3p

Accession MIMAT0000422
Description Homo sapiens hsa-miR-124-3p mature miRNA
Evidence experimental
cloned [2,4-5]
Database links
Predicted targets


  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 12554860
    Numerous microRNPs in neuronal cells containing novel microRNAs
    "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
    "RNA (2003) 9:180-186

  3. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  4. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  5. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739