miRBase entry: hsa-mir-124-2

Stem-loop hsa-mir-124-2

HGNC: MIR124-2
Homo sapiens hsa-mir-124-2 precursor miRNA
Gene family
MIPF0000021; mir-124

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR124-2 is a locus that is frequently methylated in HPV DNA testing. The methylation status of MIR124-2 is analyzed using the QIAsure Methylation Test [PMC10095339]. This test is performed at enrollment and also in follow-up specimens [PMC5338782]. MIR124-2 is the most frequently methylated locus in both the initial testing and follow-up specimens [PMC5338782]. The QIAsure Methylation Test by Qiagen is a reliable method for analyzing the methylation status of MIR124-2 [PMC10095339]. This test, along with HPV DNA testing using HC2 and full HPV genotyping by Anyplex II HPV28 Detection Kit, provides comprehensive information about the presence of HPV and methylation status of MIR124-2 [PMC10095339]. The use of these tests at enrollment allows for early detection and monitoring of HPV infection, as well as identification of methylated loci such as MIR124-2 [PMC5338782]. The frequent methylation of MIR124-2 suggests its potential as a biomarker for HPV infection and its progression [PMC5338782]. Further research can explore the clinical implications and potential therapeutic targets associated with the methylation status of MIR124-2 in HPV infection.

Literature search
428 open access papers mention hsa-mir-124-2
(3661 sentences)


97976 reads, 932 reads per million, 65 experiments

a     au   ----            cC        A   GA        uaau 
 ucaag  uag    aggcucugcucu  GUGUUCAC GCG  CCUUGAUu    g
 |||||  |||    ||||||||||||  |||||||| |||  ||||||||    u
 aguuc  guc    uccgaggcgagA  CGUAAGUG CGC  GGAAUuaa    c
a     ac   ggca            AC        G   AC        caua 

Annotation confidence High
Do you think this miRNA is real?
miR-124 was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context
chr8: 64379149-64379257 [+]

Disease association
hsa-mir-124-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-124-5p

Accession MIMAT0004591
Description Homo sapiens hsa-miR-124-5p mature miRNA
Evidence experimental
cloned [5]

Mature hsa-miR-124-3p

Accession MIMAT0000422
Description Homo sapiens hsa-miR-124-3p mature miRNA
Evidence experimental
cloned [2,4-5]
Database links
Predicted targets


  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 12554860
    Numerous microRNPs in neuronal cells containing novel microRNAs
    "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
    "RNA (2003) 9:180-186

  3. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  4. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  5. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739