miRBase entry: hsa-mir-124-3

Stem-loop hsa-mir-124-3

HGNC: MIR124-3
Homo sapiens hsa-mir-124-3 precursor miRNA
Gene family
MIPF0000021; mir-124

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR124-3 is a conserved microRNA that has been found to inhibit invasion and migration of malignant cells in ovarian cancer and hepatocellular cancer [PMC6712160]. It is one of three members of the Mir124 class, along with Mir124-1 and Mir124-2, located at different genomic positions [PMC6346295]. MIR124-3 has been shown to be hypermethylated in tumor samples, with a 16-fold difference in methylation compared to control samples [PMC8656781]. Hypermethylation of MIR124-3 has also been associated with shorter overall survival in ovarian cancer patients [PMC8835734]. Methylation levels of MIR124-3 have been found to increase significantly in primary ovarian tumors and peritoneal macroscopic metastases compared to control samples [PMC8835734]. Additionally, MIR124-3 methylation has been associated with the onset of ovarian cancer pathogenesis [PMC8835734]. MIR124-3 is one of three genes that encode the same mature miR-124, with the other two genes being MIR124-1 and MIR124-2 [PMC4861808]. It has also been found to be methylated in patients with borderline personality disorder (BPD) [PMC6252387] and is involved in neurogenesis [PMC7686352]. Furthermore, MIR124-3 is one of four microRNA genes identified as having anti-tumor roles in pancreatic ductal adenocarcinoma (PDAC) [PMC9599555]. CpG islands located in the promoters of all three miR-124 precursor genes (MIR124-1, MIR124-2, and MIR  24 - 3) have been selected for analysis due to specific criteria being met. However, it remains unclear whether the upregulation of miR-124 is directly related to the hypomethylation of the precursor genes [PMC8724533].

Literature search
423 open access papers mention hsa-mir-124-3
(3672 sentences)


97714 reads, 919 reads per million, 64 experiments

u    -   c    gC        A   GA        uaaug 
 gagg gcc cucu  GUGUUCAC GCG  CCUUGAUu     u
 |||| ||| ||||  |||||||| |||  ||||||||      
 cucc cgg gagA  CGUAAGUG CGC  GGAAUuaa     c
c    g   a    AC        G   AC        cauau 

Annotation confidence High
Do you think this miRNA is real?
miR-124 was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context
chr20: 63178500-63178586 [+]

Disease association
hsa-mir-124-3 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-124-5p

Accession MIMAT0004591
Description Homo sapiens hsa-miR-124-5p mature miRNA
Evidence experimental
cloned [5]

Mature hsa-miR-124-3p

Accession MIMAT0000422
Description Homo sapiens hsa-miR-124-3p mature miRNA
Evidence experimental
cloned [2,4-5]
Database links
Predicted targets


  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 12554860
    Numerous microRNPs in neuronal cells containing novel microRNAs
    "Dostie J, Mourelatos Z, Yang M, Sharma A, Dreyfuss G"
    "RNA (2003) 9:180-186

  3. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  4. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  5. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739