miRBase entry: hsa-mir-128-1

Stem-loop hsa-mir-128-1

HGNC: MIR128-1
Homo sapiens hsa-mir-128-1 precursor miRNA
Gene family
MIPF0000048; mir-128

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR128-1 is a microRNA gene that interacts with the CDH1 coding protein cadherin through a specific upstream protein called Bmi1, which is the direct target of MIR128-1 [PMC5320387]. MIR128-1 is part of a gene family that includes MIR128-2, and both genes encode different species of microRNAs [PMC5481840]. Specifically, MIR128-1 and MIR128-2 encode miR-128-3p species with identical mature sequences. Additionally, MIR128-1 encodes miR-128-1-5p species, while MIR128-2 encodes miR-128-2-p5 species. These two species differ slightly in their sequences [PMC5481840]. 

MicroRNAs are small non-coding RNA molecules that play important roles in gene regulation and are involved in various biological processes [PMC5320387]. The interaction between MIR128-1 and CDH1 through Bmi1 suggests a potential regulatory mechanism for cadherin expression mediated by microRNAs [PMC5320387]. The presence of different mature sequences encoded by the MIR128 genes suggests potential functional differences between the miR-p5 and miR-p3p species [PMC5481840].

Overall, these findings highlight the complexity of microRNA regulation and provide insights into the specific interactions between microRNAs and their target proteins. Further research is needed to fully understand the functional significance of these interactions in gene regulation processes.

Literature search
174 open access papers mention hsa-mir-128-1
(983 sentences)


181014 reads, 1158 reads per million, 135 experiments

u    u      uuC       UAG      CU       u 
 gagc guugga   GGGGCCG   CACUGU  GAGAggu u
 |||| ||||||   |||||||   ||||||  |||||||  
 uucg cgacuu   CUCUGGC   GUGACA  CUcuuua a
c    u      UUU       CAA      --       c 

Annotation confidence High
Do you think this miRNA is real?
The most commonly cloned mature sequences derived from the previously annotated mir-128a and mir-128b were shown by Landgraf et al to be identical [3]. The sequences are therefore renamed mir-128-1 and mir-128-2.

Genome context
chr2: 135665397-135665478 [+]

Disease association
hsa-mir-128-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-128-3p

Accession MIMAT0000424
Description Homo sapiens hsa-miR-128-3p mature miRNA
Evidence experimental
cloned [3], Illumina [4]
Database links
Predicted targets

Mature hsa-miR-128-1-5p

Accession MIMAT0026477
Description Homo sapiens hsa-miR-128-1-5p mature miRNA
Evidence experimental
Illumina [4]
Database links
Predicted targets


  1. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  4. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45