Stem-loop hsa-mir-130a

Accession

MI0000448

Symbol

HGNC: MIR130A

Description

Homo sapiens hsa-mir-130a precursor miRNA

Gene family

MIPF0000034; mir-130

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR130A is a microRNA (miRNA) that is enriched in melanoma extracellular vesicles (EVs) and has been associated with melanoma metastasis [PMC9871288]. Recent studies have shown that inhibiting MIR130A in cerebral ischemia can have beneficial effects, such as reducing blood-brain barrier (BBB) permeability, brain edema, and improving neurological function [PMC6732937].

Literature search

188 open access papers mention hsa-mir-130a
(1154 sentences)

Sequence

162102 reads, 2307 reads per million, 131 experiments

ugcugcuggccagaGCUCUUUUCACAUUGUGCUACUgucugcaccugucacuagCAGUGCAAUGUUAAAAGGGCAUuggccguguagug
.((((((((((((.((((((((.((((((((((.(((...((....))...))).)))))))))).)))))))).))))))).))))).

Structure

u     -       a        C          A   ucu  a 
 gcugc uggccag GCUCUUUU ACAUUGUGCU CUg   gc c
 ||||| ||||||| |||||||| |||||||||| |||   ||  
 ugaug gccgguU CGGGAAAA UGUAACGUGA gau   ug c
g     u       A        U          C   cac  u 

Annotation confidence High

Comments

miR-130a was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2].

Genome context

chr11: 57641198-57641286 [+]

Disease association

hsa-mir-130a is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-130a-5p

• Accession: MIMAT0004593
• Description: Homo sapiens hsa-miR-130a-5p mature miRNA
• Sequence: 15 - GCUCUUUUCACAUUGUGCUACU - 36
• Evidence: experimental ; cloned [3]

Mature hsa-miR-130a-3p

• Accession: MIMAT0000425
• Description: Homo sapiens hsa-miR-130a-3p mature miRNA
• Sequence: 55 - CAGUGCAAUGUUAAAAGGGCAU - 76
• Evidence: experimental ; cloned [2-4], Northern [2]

References

1. PubMed ID: 15183728
   Human embryonic stem cells express a unique set of microRNAs
   "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
   "Dev Biol (2004) 270:488-498


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 17616659
   Patterns of known and novel small RNAs in human cervical cancer
   "Lui WO, Pourmand N, Patterson BK, Fire A"
   "Cancer Res (2007) 67:6031-6043


4. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739