Stem-loop hsa-mir-133a-1

Accession

MI0000450

Symbol

HGNC: MIR133A1

Description

Homo sapiens hsa-mir-133a-1 precursor miRNA

Literature search

384 open access papers mention hsa-mir-133a-1
(1856 sentences)

Sequence

29524 reads, 247 reads per million, 119 experiments

acaaugcuuugcuagAGCUGGUAAAAUGGAACCAAAUcgccucuucaauggaUUUGGUCCCCUUCAACCAGCUGuagcuaugcauuga
.((((((...((((.(((((((..((.((.((((((((............)))))))).)).))..))))))).))))...)))))).

Structure

a      uuu    g       AA  U  A        gccuc 
 caaugc   gcua AGCUGGU  AA GG ACCAAAUc     u
 ||||||   |||| |||||||  || || ||||||||      
 guuacg   cgau UCGACCA  UU CC UGGUUUag     u
a      uau    G       AC  C  C        guaac 

Annotation confidence High

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context

chr18: 21825698-21825785 [-]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-133a-1

Disease association

hsa-mir-133a-1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-133a-3p

• Accession: MIMAT0000427
• Description: Homo sapiens hsa-miR-133a-3p mature miRNA
• Sequence: 53 - UUUGGUCCCCUUCAACCAGCUG - 74
• Evidence: experimental ; cloned [2], Illumina [3]

Mature hsa-miR-133a-5p

• Accession: MIMAT0026478
• Description: Homo sapiens hsa-miR-133a-5p mature miRNA
• Sequence: 16 - AGCUGGUAAAAUGGAACCAAAU - 37
• Evidence: experimental ; Illumina [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


3. PubMed ID: 23034410
   Birth and expression evolution of mammalian microRNA genes
   "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
   "Genome Res (2013) 23:34-45