miRBase entry: hsa-mir-133a-2

Stem-loop hsa-mir-133a-2


Accession
MI0000451
Symbol
HGNC: MIR133A2
Description
Homo sapiens hsa-mir-133a-2 precursor miRNA

Literature search
381 open access papers mention hsa-mir-133a-2
(1828 sentences)

Sequence

29569 reads, 247 reads per million, 119 experiments
gggagccaaaugcuuugcuagAGCUGGUAAAAUGGAACCAAAUcgacuguccaauggaUUUGGUCCCCUUCAACCAGCUGuagcugugcauugauggcgccg
.((.(((((((((...((((.(((((((..((.((.((((((((.(........).)))))))).)).))..))))))).))))...)))))..)))).)).

Structure
g  a    --     uuu    g       AA  U  A        g cug 
 gg gcca  aaugc   gcua AGCUGGU  AA GG ACCAAAUc a   u
 || ||||  |||||   |||| |||||||  || || |||||||| |    
 cc cggu  uuacg   cgau UCGACCA  UU CC UGGUUUag u   c
g  g    ag     ugu    G       AC  C  C        g aac 


Annotation confidence Medium
Do you think this miRNA is real?
Comments
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1] later verified in human [2].

Genome context
chr20: 62564912-62565013 [+]

Disease association
hsa-mir-133a-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-133a-3p

Accession MIMAT0000427
Description Homo sapiens hsa-miR-133a-3p mature miRNA
Sequence 59 - UUUGGUCCCCUUCAACCAGCUG - 80
Evidence experimental
cloned [2], Illumina [3]
Database links
Predicted targets

Mature hsa-miR-133a-5p

Accession MIMAT0026478
Description Homo sapiens hsa-miR-133a-5p mature miRNA
Sequence 22 - AGCUGGUAAAAUGGAACCAAAU - 43
Evidence experimental
Illumina [3]
Database links
Predicted targets

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  3. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45