miRBase entry: hsa-mir-135a-1

Stem-loop hsa-mir-135a-1

Homo sapiens hsa-mir-135a-1 precursor miRNA
Gene family
MIPF0000028; mir-135

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR135A1 is a member of the miR135a family in mice [PMC3861205]. It is located in the human chromosome 3p21.2 region [PMC10101835]. This region contains not only well-known protein-coding tumor suppressor genes (TSGs) like TP53 but also six microRNAs, including MIR135A1 [PMC5001246]. MIR135A1 is under regulatory control of NIR17 and MIR135B [PMC3948699]. The promoter region of the MIR135A1 gene does not show differential methylation status between different clusters [PMC9885701]. The CNVs (copy number variations) of the genes encoding miR-135a-5p transcript, including MIR135A1, do not show significantly different frequencies of alteration between clusters [PMC9885701]. Promoter sequences of the MIR135A1 gene were retrieved from UCSC using R/Bioconductor packages BSgenome.Hsapiens.UCSC.hg19 [PMC9885701]. Transcription factor binding sites were searched in the promoter sequences of both MIR135A1 and MIR135A2 genes to understand their transcriptional regulation [PMC9885701]. MiR-135a is encoded by two genes: MIR135A1 on human chromosome 3 and MIR135A2 on human chromosome 12 [PMC9160269]. MiR-135b is encoded by the MIR135B gene located on human chromosome 1q32.1 [PMC7476096]. Frequent deletion or amplification of the loci for miR-135, including MIR135A1, MIR135A2, and MIR135B, may be associated with dysregulation of certain members of this family and poor prognosis in primary breast cancers [PMC9486161].

Literature search
153 open access papers mention hsa-mir-135a-1
(512 sentences)


7503 reads, 227 reads per million, 117 experiments

agg         u u          UU            uucua 
   ccucgcugu c cUAUGGCUUU  AUUCCUAUGUGA     c
   ||||||||| | ||||||||||  ||||||||||||     u
   ggggcggca G GGUGCCGAGG  UAGGGAUAUacu     g
aca         c C          -U            cacuc 

Annotation confidence High
Do you think this miRNA is real?
miR-135a was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2].

Genome context
chr3: 52294219-52294308 [-]

Disease association
hsa-mir-135a-1 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-135a-5p

Accession MIMAT0000428
Description Homo sapiens hsa-miR-135a-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-135a-3p

Accession MIMAT0004595
Description Homo sapiens hsa-miR-135a-3p mature miRNA
Evidence experimental
cloned [3]
Database links
Predicted targets


  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739