Accession
MI0000453
Symbol
HGNC:
MIR135A2
Description
Homo sapiens
hsa-mir-135a-2 precursor miRNA
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR135A2 is a microRNA implicated in the modulation of midbrain development through the repression of the gene Lmx1b [PMC3861205]. Research involving luciferase assays in HEK293 cells demonstrated that MIR135A2 could repress a reporter construct containing a segment of the Lmx1b 3′ untranslated region (UTR) [PMC3861205]. However, this repression did not occur when mutations were introduced into the MIR135A2 binding sites within the Lmx1b 3′UTR, underscoring the specificity of MIR135A2's interaction with its target [PMC3861205]. These findings suggest that MIR135A2 has a functional role in midbrain development by directly targeting and regulating Lmx1b expression [PMC3861205].
Literature search
151 open access papers mention hsa-mir-135a-2
(509 sentences)
(509 sentences)
Sequence
7823
reads,
32
reads per million, 92 experiments
agauaaauucacucuagugcuuUAUGGCUUUUUAUUCCUAUGUGAuaguaauaaagucucAUGUAGGGAUGGAAGCCAUGAAauacauugugaaaaauca
.(((...(((((....(((.((((((((((((.((((((((((((.(.(.....).).)))))))))))))))))))))))).)))...)))))..))).
.(((...(((((....(((.((((((((((((.((((((((((((.(.(.....).).)))))))))))))))))))))))).)))...)))))..))).
Structure
a aaa ucua c U u g a gau uucac gug uuUAUGGCUUUU AUUCCUAUGUGA a u a ||| ||||| ||| |||||||||||| |||||||||||| | | u cua aagug cau AAGUACCGAAGG UAGGGAUGUAcu u a a a -aa -uua a - c g a
Annotation confidence
High
Do you think this miRNA is real?
Comments
miR-135a was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2].
Genome context
chr12: 97563812-97563911 [+]
Disease association
hsa-mir-135a-2 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-135a-5p
| Accession | MIMAT0000428 |
| Description | Homo sapiens hsa-miR-135a-5p mature miRNA |
| Sequence | 23 - UAUGGCUUUUUAUUCCUAUGUGA - 45 |
| Evidence |
experimental
cloned [2-3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-135a-2-3p
| Accession | MIMAT0037309 |
| Description | Homo sapiens hsa-miR-135a-2-3p mature miRNA |
| Sequence | 61 - AUGUAGGGAUGGAAGCCAUGAA - 82 |
| Evidence | not_experimental |
References
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