Accession
MI0000458
Symbol
HGNC:
MIR142
Description
Homo sapiens
hsa-mir-142 precursor miRNA mir-142
Gene
family?
family?
RF01896;
mir-142
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR142 is a microRNA implicated in various biological processes and diseases, including leukemogenesis and intestinal inflammation. In Sgca-/- mice, a vector regulated by MIR142.3p showed decreased transgene expression over time [PMC4283385]. MIR142−/− mice were created by excising the MIR142 region in mouse embryonic stem cells, facilitating the study of its functions [PMC6910913]. Research on the synergy between MIR142 and IDH2R140Q mutations in leukemogenesis highlighted the importance of MIR142's presence or absence [PMC7656267]. An analysis of 672 samples across different myeloproliferative neoplasms (MPNs) included examining mutations in MIR142 [PMC9240003]. Additionally, MIR142 has been identified as an autophagy-regulating molecule that targets ATG16L1, linking it to Crohn's disease [PMC6351131]. In the context of chronic alcohol consumption, it has been found that sperm microRNA composition is altered, including changes in levels of MIR142; however, these changes are not associated with corticosterone levels but may be related to epididymal trafficking [PMC9886817]. Furthermore, it has been established that among microRNAs, both MIR24 and MIR142 are significant due to their ability to target over 1,000 genes each [PMC7287171]. Lastly, vectors containing GFP controlled by a promoter hybrid including sequences of MIR142 were purified for experimental use [PMC7184633].
Literature search
284 open access papers mention hsa-mir-142
(1956 sentences)
(1956 sentences)
Sequence
381614
reads,
4761
reads per million, 132 experiments
gacagugcagucaccCAUAAAGUAGAAAGCACUACUaacagcacuggagggUGUAGUGUUUCCUACUUUAUGGAugaguguacugug
.((((((((.(((.(((((((((((.(((((((((...(..(....)..)..))))))))).))))))))))).))).)))))))).
.((((((((.(((.(((((((((((.(((((((((...(..(....)..)..))))))))).))))))))))).))).)))))))).
Structure
g g c A Uaa ag a acagugca uca cCAUAAAGUAG AAGCACUAC c c c |||||||| ||| ||||||||||| ||||||||| | | ugucaugu agu GGUAUUUCAUC UUUGUGAUG g g u g g A C -Ug ga g
Annotation confidence
High
Do you think this miRNA is real?
Comments
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. Michael et al. verified the expression of a sequence from the 3' arm of this stem-loop (named miR-142-3p here) [2], and both miR-142-5p (from the 5' arm) and miR-142-3p ware later detected in human HL-60 leukemia cells [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].
Genome context
chr17: 58331232-58331318 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-142
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-142 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-142-5p
| Accession | MIMAT0000433 |
| Description | Homo sapiens hsa-miR-142-5p mature miRNA |
| Sequence | 16 - CAUAAAGUAGAAAGCACUACU - 36 |
| Evidence |
experimental
cloned [3-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-142-3p
| Accession | MIMAT0000434 |
| Description | Homo sapiens hsa-miR-142-3p mature miRNA |
| Sequence | 52 - UGUAGUGUUUCCUACUUUAUGGA - 74 |
| Evidence |
experimental
cloned [2-4] |
| Database links |
|
| Predicted targets |
|
References
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