miRBase entry: hsa-mir-142

Stem-loop hsa-mir-142

Homo sapiens hsa-mir-142 precursor miRNA
Gene family
MIPF0000084; mir-142

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR142 is a small molecule that plays a role in various biological processes. In Sgca-/- mice, the expression of MIR142.3p-regulated vector decreased over time [PMC4283385]. MIR142−/− mice, which lack the MIR142 region, were obtained from the mouse facility of the German Center for Lung Research [PMC6910913]. The interaction between MIR142 and IDHR140 mutations in leukemogenesis was investigated [PMC7656267]. The occurrence of mutations in MIR142 was analyzed in a collection of samples from patients with myeloproliferative neoplasms (MPNs) [PMC9240003]. MIR142 was found to regulate autophagy by targeting ATG16L1, suggesting its involvement in intestinal inflammation and Crohn's disease [PMC6351131]. Chronic alcohol consumption was found to alter the expression of MIR142, among other small RNAs and microRNAs, which may be mediated by effects on epididymal trafficking rather than changes in corticosterone levels [PMC9886817]. Additionally, MIR24 and MIR142 were identified as miRNAs that target over 1,000 genes each [PMC7287171]. AAV2 plasmids containing the gene encoding GFP under the control of a hybrid sequence including 4 repeated sequences of MIR142 were used for vector purification [PMC7184633]. Overall, these studies highlight the diverse roles and regulatory functions of MIR142 in various biological processes.

Literature search
284 open access papers mention hsa-mir-142
(1956 sentences)


381614 reads, 4761 reads per million, 132 experiments

g        g   c           A         Uaa ag a 
 acagugca uca cCAUAAAGUAG AAGCACUAC   c  c c
 |||||||| ||| ||||||||||| |||||||||   |  |  
 ugucaugu agu GGUAUUUCAUC UUUGUGAUG   g  g u
g        g   A           C         -Ug ga g 

Annotation confidence High
Do you think this miRNA is real?
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. Michael et al. verified the expression of a sequence from the 3' arm of this stem-loop (named miR-142-3p here) [2], and both miR-142-5p (from the 5' arm) and miR-142-3p ware later detected in human HL-60 leukemia cells [3]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context
chr17: 58331232-58331318 [-]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-142
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-142 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-142-5p

Accession MIMAT0000433
Description Homo sapiens hsa-miR-142-5p mature miRNA
Evidence experimental
cloned [3-4]
Database links
Predicted targets

Mature hsa-miR-142-3p

Accession MIMAT0000434
Description Homo sapiens hsa-miR-142-3p mature miRNA
Evidence experimental
cloned [2-4]
Database links
Predicted targets


  1. PubMed ID: 14573789
    Reduced accumulation of specific microRNAs in colorectal neoplasia
    "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
    "Mol Cancer Res (2003) 1:882-891

  2. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  3. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  4. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739