miRBase entry: hsa-mir-144

Stem-loop hsa-mir-144

Homo sapiens hsa-mir-144 precursor miRNA
Gene family
MIPF0000093; mir-144

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR144 is a microRNA that has been found to downregulate the activity of the MAP3K8/ERK1/2/PPARγ axes, leading to the induction of brown/beige-like characteristics in differentiated adipocytes [PMC9779381]. Overexpression of MIR144 has been shown to significantly increase the expression of human GRβ, while not affecting GRα [PMC5053652]. MIR144, along with miR153, miR27a, and miR142-5p, has been found to inhibit the interaction and binding of these microRNAs with the 3' UTR of human Nrf2, indicating Nrf2 as a direct regulatory target [PMC3517581]. Additionally, MIR144 has been shown to decrease both c-Met and ADAM10 mRNA levels [PMC7352235]. It is worth noting that components of the AP1 complex have been found to regulate the expression of various microRNAs including MIR144 [PMC7123062]. However, other studies have reported an increase in MIR144 levels in colorectal cancer [PMC4599290].

MIR144 is a microRNA that plays a role in regulating various cellular processes. It downregulates MAP3K8/ERK1/2/PPARγ axes activity and induces brown/beige-like characteristics in adipocytes. It also affects GRβ expression and inhibits interaction with Nrf2. Additionally, it reduces c-Met and ADAM10 mRNA levels. However, its role in colorectal cancer is still not fully understood.

Literature search
164 open access papers mention hsa-mir-144
(963 sentences)


120704 reads, 1971 reads per million, 101 experiments

-u   -    u      G        A         -A    gc 
  ggg gccc ggcugG AUAUCAUC UAUACUGUA  Guuu  g
  ||| |||| |||||| |||||||| |||||||||  ||||   
  ccc cggg cugaUC UGUAGUAG AUAUGACAU  caga  a
cc   a    c      A        -         ca    gu 

Annotation confidence High
Do you think this miRNA is real?
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. The expression of this miRNA has not been verified in human. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [2].

Genome context
chr17: 28861533-28861618 [-]
Clustered miRNAs
3 other miRNAs are < 10 kb from hsa-mir-144
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-144 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-144 is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-144 is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-144-5p

Accession MIMAT0004600
Description Homo sapiens hsa-miR-144-5p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets

Mature hsa-miR-144-3p

Accession MIMAT0000436
Description Homo sapiens hsa-miR-144-3p mature miRNA
Evidence experimental
cloned [2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739