Stem-loop hsa-mir-145

Accession

MI0000461

Symbol

HGNC: MIR145

Description

Homo sapiens hsa-mir-145 precursor miRNA mir-145

Gene
family

RF00675; mir-145

Literature search

668 open access papers mention hsa-mir-145
(4250 sentences)

Sequence

1428617 reads, 20797 reads per million, 150 experiments

caccuuguccucacgGUCCAGUUUUCCCAGGAAUCCCUuagaugcuaagauggGGAUUCCUGGAAAUACUGUUCUugaggucaugguu
.(((.((.(((((.((..((((.((.((((((((((((.............)))))))))))).)).))))..))))))).)).))).

Structure

c   u  u     c  UC    U  C            uagau 
 acc ug ccuca gG  CAGU UU CCAGGAAUCCCU     g
 ||| || ||||| ||  |||| || ||||||||||||     c
 ugg ac ggagu UC  GUCA AA GGUCCUUAGGgg     u
u   u  u     -  UU    U  A            uagaa 

Annotation confidence High

Comments

This miRNA sequence was predicted based on homology to a verified miRNA from mouse [1]. Michael et al. subsequently verified expression of miR-145 in human, and demonstrated significantly reduced levels of the miRNA in precancerous and neoplastic colorectal tissue [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context

chr5: 149430646-149430733 [+]

Clustered miRNAs

1 other miRNA is < 10 kb from hsa-mir-145

Disease association

hsa-mir-145 is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-145 is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-145 is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-145-5p

• Accession: MIMAT0000437
• Description: Homo sapiens hsa-miR-145-5p mature miRNA
• Sequence: 16 - GUCCAGUUUUCCCAGGAAUCCCU - 38
• Evidence: experimental ; cloned [2-4]

Mature hsa-miR-145-3p

• Accession: MIMAT0004601
• Description: Homo sapiens hsa-miR-145-3p mature miRNA
• Sequence: 54 - GGAUUCCUGGAAAUACUGUUCU - 75
• Evidence: experimental ; cloned [4]

References

1. PubMed ID: 14573789
   Reduced accumulation of specific microRNAs in colorectal neoplasia
   "Michael MZ, O' Connor SM, van Holst Pellekaan NG, Young GP, James RJ"
   "Mol Cancer Res (2003) 1:882-891


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 15978578
   Identification of human fetal liver miRNAs by a novel method
   "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
   "FEBS Lett (2005) 579:3849-3854


4. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739