Stem-loop hsa-mir-9-3

Accession

MI0000468

Symbol

HGNC: MIR9-3

Description

Homo sapiens hsa-mir-9-3 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR9-3 is one of the 12 common genes that showed methylation in both primary tumors associated with metastasis and advanced stages [PMC8835734]. The methylation status of the three MIR9 promoters, including MIR9-3, was analyzed using Methylation Specific PCR (MSP) [PMC5366901]. The primer sets used in the analysis were designed based on the CpG region encompassing the transcription start sites of MIR9 genes, which were validated by RACE [PMC5366901]. MIR9-1, MIR9-2, and MIR9-3 are located on chromosomes 1, 5, and 15 respectively [PMC9220270].

Literature search

542 open access papers mention hsa-mir-9-3
(3363 sentences)

Sequence

663593 reads, 2765 reads per million, 111 experiments

ggaggcccguuucucUCUUUGGUUAUCUAGCUGUAUGAgugccacagagccgucAUAAAGCUAGAUAACCGAAAGUagaaaugauucuca
.((((..(((((((((.(((((((((((((((.(((((..((......))..))))).))))))))))))))))).)))))))..)))).

Structure

g    cc       -  C               G     gu  ca 
 gagg  cguuucu cU UUUGGUUAUCUAGCU UAUGA  gc  c
 ||||  ||||||| || ||||||||||||||| |||||  ||   
 cucu  guaaaga GA AAGCCAAUAGAUCGA AUAcu  cg  a
a    ua       U  -               A     gc  ag 

Annotation confidence High

Genome context

chr15: 89368017-89368106 [+]

Disease association

hsa-mir-9-3 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-9-5p

• Accession: MIMAT0000441
• Description: Homo sapiens hsa-miR-9-5p mature miRNA
• Sequence: 16 - UCUUUGGUUAUCUAGCUGUAUGA - 38
• Evidence: experimental ; cloned [2]

Mature hsa-miR-9-3p

• Accession: MIMAT0000442
• Description: Homo sapiens hsa-miR-9-3p mature miRNA
• Sequence: 55 - AUAAAGCUAGAUAACCGAAAGU - 76
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739