MIR126 is a microRNA that has been studied in various contexts. It has been found to be downregulated in the retinal tissue of streptozotocin-induced diabetic rats [PMC7932804]. In human lung tissue, there is a significant inverse correlation between ADAM9 expression and MIR126 expression [PMC9756782]. Disruption of MIR126, but not EGFL7, has been shown to lead to phenotypic changes in animals [PMC3960138]. MIR126 has also been found to induce complex metabolic reprogramming of MM cells, including activation of the autophagic pathway and downregulation of PDK and ACL activity [PMC5095004]. In AFS cells, MIR126 is detectable at the basal state [PMC4628318]. It plays a role in altering energy metabolism and facilitating tumor progression [PMC9779381]. Low levels of MIR126 are associated with a high risk for CoAD [PMC7123062]. The expression pattern of caspase 3 and MIR126 in EPCs is similar to that in their parent cells [PMC3830832]. In patients with PAAD, MIR126 is significantly associated with overall survival [PMC6005310]. The downregulation of miR-106a, miR-146a, miR-150, miR-16, miR-17, miR-19b, miR-20a, miR-223, miR-24, and miR-92a has also been observed in ovarian cancer samples compared to control samples [PMC6571871]. Housekeepers such as miRNA191 were measured against MIR126 and other microRNAs for comparison purposes.
c gc ga U CGcug c gcug gacgg CAUUAUUACUU UGGUACG uga a |||| ||||| ||||||||||| ||||||| ||| cggc cugcc GUAAUAAUGAG GCCAUGC acu c a ac GC U -Ucaa u
Disease | Description | Category | PubMed ID |
---|
Accession | MIMAT0000444 |
Description | Homo sapiens hsa-miR-126-5p mature miRNA |
Sequence | 15 - CAUUAUUACUUUUGGUACGCG - 35 |
Evidence |
experimental
cloned [2] |
Database links | |
Predicted targets |
Accession | MIMAT0000445 |
Description | Homo sapiens hsa-miR-126-3p mature miRNA |
Sequence | 52 - UCGUACCGUGAGUAAUAAUGCG - 73 |
Evidence |
experimental
cloned [2] |
Database links | |
Predicted targets |
|