Accession
MI0000471
Symbol
HGNC:
MIR126
Description
Homo sapiens
hsa-mir-126 precursor miRNA mir-126
Gene
family?
family?
RF00701;
mir-126
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR126 is a microRNA that has been studied in various contexts. It has been found to be downregulated in the retinal tissue of streptozotocin-induced diabetic rats [PMC7932804]. In human lung tissue, there is a significant inverse correlation between ADAM9 expression and MIR126 expression [PMC9756782]. Disruption of MIR126, but not EGFL7, has been shown to lead to phenotypic changes in animals [PMC3960138]. MIR126 has also been found to induce complex metabolic reprogramming of MM cells, including activation of the autophagic pathway and downregulation of PDK and ACL activity [PMC5095004]. In AFS cells, MIR126 is detectable at the basal state [PMC4628318]. It plays a role in altering energy metabolism and facilitating tumor progression [PMC9779381]. Low levels of MIR126 are associated with a high risk for CoAD [PMC7123062]. The expression pattern of caspase 3 and MIR126 in EPCs is similar to that in their parent cells [PMC3830832]. In patients with PAAD, MIR126 is significantly associated with overall survival [PMC6005310]. The downregulation of miR-106a, miR-146a, miR-150, miR-16, miR-17, miR-19b, miR-20a, miR-223, miR-24, and miR-92a has also been observed in ovarian cancer samples compared to control samples [PMC6571871]. Housekeepers such as miRNA191 were measured against MIR126 and other microRNAs for comparison purposes.
Literature search
445 open access papers mention hsa-mir-126
(2777 sentences)
(2777 sentences)
Sequence
718142
reads,
4188
reads per million, 135 experiments
cgcuggcgacgggaCAUUAUUACUUUUGGUACGCGcugugacacuucaaacUCGUACCGUGAGUAAUAAUGCGccguccacggca
.((((..(((((..(((((((((((.(((((((.....(((....)))....))))))).)))))))))))..)))))..)))).
.((((..(((((..(((((((((((.(((((((.....(((....)))....))))))).)))))))))))..)))))..)))).
Structure
c gc ga U CGcug c gcug gacgg CAUUAUUACUU UGGUACG uga a |||| ||||| ||||||||||| ||||||| ||| cggc cugcc GUAAUAAUGAG GCCAUGC acu c a ac GC U -Ucaa u
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr9: 136670602-136670686 [+]
Disease association
hsa-mir-126 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-126-5p
| Accession | MIMAT0000444 |
| Description | Homo sapiens hsa-miR-126-5p mature miRNA |
| Sequence | 15 - CAUUAUUACUUUUGGUACGCG - 35 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-126-3p
| Accession | MIMAT0000445 |
| Description | Homo sapiens hsa-miR-126-3p mature miRNA |
| Sequence | 52 - UCGUACCGUGAGUAAUAAUGCG - 73 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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