Stem-loop hsa-mir-129-2

Accession

MI0000473

Symbol

HGNC: MIR129-2

Description

Homo sapiens hsa-mir-129-2 precursor miRNA

Literature search

136 open access papers mention hsa-mir-129-2
(1245 sentences)

Sequence

66020 reads, 127 reads per million, 95 experiments

ugcccuucgcgaauCUUUUUGCGGUCUGGGCUUGCuguacauaacucaauagccggAAGCCCUUACCCCAAAAAGCAUuugcggagggcg
.((((((((((((((((((((.(((..(((((((((((..........)))))...))))))..))).))))))).))))))))))))).

Structure

u             -       C   CU      ---     acau 
 gcccuucgcgaau CUUUUUG GGU  GGGCUU   GCugu    a
 ||||||||||||| ||||||| |||  ||||||   |||||     
 cgggaggcguuUA GAAAAAC CCA  CCCGAA   cgaua    a
g             C       C   UU      ggc     acuc 

Annotation confidence High

Comments

This miRNA sequence was predicted based on homology to a verified miRNA cloned from mouse cerebellum [1]. Expression of this miRNA was subsequently verified in a human osteoblast sarcoma cell line [2]. Reference [2] named the human/mouse conserved sequence miR-129b, but subsequent genome searches suggest that the same mature sequence may be expressed from two predicted hairpin precursors in both human (this entry and MIR:MI0000252) and mouse (MIR:MI0000222 and MIR:MI0000585). Landgraf et al. show that the 5' product of mir-129-1 (MIR:MI0000222) is the predominant one, whereas both 5' and 3' products are significantly expressed from mir-129-2 (this entry) [3].

Genome context

chr11: 43581394-43581483 [+]

Disease association

hsa-mir-129-2 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-129-5p

• Accession: MIMAT0000242
• Description: Homo sapiens hsa-miR-129-5p mature miRNA
• Sequence: 15 - CUUUUUGCGGUCUGGGCUUGC - 35
• Evidence: experimental ; cloned [2-3]

Mature hsa-miR-129-2-3p

• Accession: MIMAT0004605
• Description: Homo sapiens hsa-miR-129-2-3p mature miRNA
• Sequence: 57 - AAGCCCUUACCCCAAAAAGCAU - 78
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12554859
   New microRNAs from mouse and human
   "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
   "RNA (2003) 9:175-179


3. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739