miRBase entry: hsa-mir-134

Stem-loop hsa-mir-134

Homo sapiens hsa-mir-134 precursor miRNA
Gene family
MIPF0000112; mir-134

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR134 is a brain-enriched miRNA that is involved in various processes such as cell growth, differentiation, synaptic plasticity, neuroinflammation, and apoptosis [PMC6994828]. It has been found that knockdown of MIR134 in the ventral hippocampus (vHP) enhances the development of long-term potentiation (LTP) in CA1 pyramidal neurons [PMC6994828]. Dysregulation of miRNA biogenesis and increased levels of MIR134 have been observed in epilepsy and neurodegenerative disorders [PMC6994828]. In animal models, reducing brain levels of MIR134 has been shown to protect against seizures [PMC8178478]. In the context of cocaine exposure, knockdown of MIR134 expression in the vHP reduces anxiety-like and depression-like behaviors [PMC6994828]. MIR134 is expressed near synaptic sites on dendrites and enriched in synaptoneurosome [PMC6994828]. It has also been shown to be involved in cell proliferation and migration regulation [PMC5928554]. Additionally, MIR134 is a putative regulator of INA (inhibin alpha subunit) and acts on translation initiation factor like 5A-1/2 [PMC7281098] [PMC7753210]. Overall, these findings suggest that MIR134 plays a significant role in various neurological processes and may have therapeutic potential for conditions such as epilepsy and cocaine addiction.

Literature search
151 open access papers mention hsa-mir-134
(805 sentences)


35267 reads, 491 reads per million, 99 experiments

c     gU        U  -A   G    ---    g 
 agggu  GUGACUGG UG  CCA AGGG   Gcau c
 |||||  |||||||| ||  ||| ||||   |||| a
 ucccA  CACUGAUC AC  GGU UCCc   ugug c
c     AC        C  CG   G    acu    u 

Annotation confidence High
Do you think this miRNA is real?
miR-134 was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].

Genome context
chr14: 101054687-101054759 [+]
Clustered miRNAs
15 other miRNAs are < 10 kb from hsa-mir-134
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-134 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-134-5p

Accession MIMAT0000447
Description Homo sapiens hsa-miR-134-5p mature miRNA
Evidence experimental
cloned [2-4], Illumina [5]
Database links
Predicted targets

Mature hsa-miR-134-3p

Accession MIMAT0026481
Description Homo sapiens hsa-miR-134-3p mature miRNA
Evidence experimental
Illumina [5]
Database links
Predicted targets


  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  4. PubMed ID: 15891114
    Clustering and conservation patterns of human microRNAs
    "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
    "Nucleic Acids Res (2005) 33:2697-2706

  5. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45