Accession
MI0000474
Symbol
HGNC:
MIR134
Description
Homo sapiens
hsa-mir-134 precursor miRNA
Gene family
MIPF0000112;
mir-134
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR134 is a brain-enriched miRNA that is involved in various processes such as cell growth, differentiation, synaptic plasticity, neuroinflammation, and apoptosis [PMC6994828]. It has been found that knockdown of MIR134 in the ventral hippocampus (vHP) enhances the development of long-term potentiation (LTP) in CA1 pyramidal neurons [PMC6994828]. Dysregulation of miRNA biogenesis and increased levels of MIR134 have been observed in epilepsy and neurodegenerative disorders [PMC6994828]. In animal models, reducing brain levels of MIR134 has been shown to protect against seizures [PMC8178478]. In the context of cocaine exposure, knockdown of MIR134 expression in the vHP reduces anxiety-like and depression-like behaviors [PMC6994828]. MIR134 is expressed near synaptic sites on dendrites and enriched in synaptoneurosome [PMC6994828]. It has also been shown to be involved in cell proliferation and migration regulation [PMC5928554]. Additionally, MIR134 is a putative regulator of INA (inhibin alpha subunit) and acts on translation initiation factor like 5A-1/2 [PMC7281098] [PMC7753210]. Overall, these findings suggest that MIR134 plays a significant role in various neurological processes and may have therapeutic potential for conditions such as epilepsy and cocaine addiction.
Literature search
151 open access papers mention hsa-mir-134
(805 sentences)
(805 sentences)
Sequence
35267
reads,
491
reads per million, 99 experiments
cagggugUGUGACUGGUUGACCAGAGGGGcaugcacuguguucacCCUGUGGGCCACCUAGUCACCAAcccuc
.(((((..((((((((.((.(((.((((((((.....))))...)))).)))..)).))))))))..))))).
.(((((..((((((((.((.(((.((((((((.....))))...)))).)))..)).))))))))..))))).
Structure
c gU U -A G --- g agggu GUGACUGG UG CCA AGGG Gcau c ||||| |||||||| || ||| |||| |||| a ucccA CACUGAUC AC GGU UCCc ugug c c AC C CG G acu u
Annotation confidence
High
Do you think this miRNA is real?
Comments
miR-134 was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4].
Genome context
chr14: 101054687-101054759 [+]
Clustered miRNAs
15 other miRNAs are < 10 kb from hsa-mir-134
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-134 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-134-5p
| Accession | MIMAT0000447 |
| Description | Homo sapiens hsa-miR-134-5p mature miRNA |
| Sequence | 8 - UGUGACUGGUUGACCAGAGGGG - 29 |
| Evidence |
experimental
cloned [2-4], Illumina [5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-134-3p
| Accession | MIMAT0026481 |
| Description | Homo sapiens hsa-miR-134-3p mature miRNA |
| Sequence | 46 - CCUGUGGGCCACCUAGUCACCAA - 68 |
| Evidence |
experimental
Illumina [5] |
| Database links |
|
| Predicted targets |
|
References
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