Accession
MI0000475
Symbol
HGNC:
MIR136
Description
Homo sapiens
hsa-mir-136 precursor miRNA mir-136
Gene
family?
family?
RF00687;
mir-136
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR136 is a microRNA observed to increase in expression levels during the transition of preadipocytes to mature adipocytes, particularly between the 8th and 10th day of adipocyte development [PMC9928478]. Concurrently, the expression of PPARGC1B, a gene implicated in this differentiation process, decreases [PMC9928478]. The study conducted an analysis to understand MIR136's role in preadipocyte proliferation and differentiation, as well as its regulatory interactions with PPARGC1B and other key adipogenic factors such as PPARγ, C/EBPα, and IGF1 [PMC9928478].
Literature search
73 open access papers mention hsa-mir-136
(354 sentences)
(354 sentences)
Sequence
14705
reads,
338
reads per million, 101 experiments
ugagcccucggaggACUCCAUUUGUUUUGAUGAUGGAuucuuaugcucCAUCAUCGUCUCAAAUGAGUCUucagaggguucu
.((((((((.((((((((.(((((...((((((((((.........))))))))))...))))))))))))).)))))))).
.((((((((.((((((((.(((((...((((((((((.........))))))))))...))))))))))))).)))))))).
Structure
u g C UUU uuc gagcccuc gaggACUC AUUUG UGAUGAUGGA u |||||||| |||||||| ||||| |||||||||| u cuugggag cuUCUGAG UAAAC GCUACUACcu a u a - UCU cgu
Annotation confidence
High
Do you think this miRNA is real?
Comments
miR-136 was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2].
Genome context
chr14: 100884702-100884783 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-136
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-136 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-136-5p
| Accession | MIMAT0000448 |
| Description | Homo sapiens hsa-miR-136-5p mature miRNA |
| Sequence | 15 - ACUCCAUUUGUUUUGAUGAUGGA - 37 |
| Evidence |
experimental
cloned [2-4] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-136-3p
| Accession | MIMAT0004606 |
| Description | Homo sapiens hsa-miR-136-3p mature miRNA |
| Sequence | 49 - CAUCAUCGUCUCAAAUGAGUCU - 70 |
| Evidence |
experimental
cloned [4] |
| Database links |
|
| Predicted targets |
|
References
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