miRBase entry: hsa-mir-136

Stem-loop hsa-mir-136

Homo sapiens hsa-mir-136 precursor miRNA
Gene family
MIPF0000099; mir-136

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR136 is a microRNA that plays a role in the proliferation and differentiation of preadipocytes. After preadipocytes successfully differentiate into mature adipocytes, the expression of PPARGC1B decreases, while the level of MIR136 increases [PMC9928478]. The regulatory mechanism of MIR136 involves the function of PPARGC1B, PPARγ, C/EBPα, and IGF1 [PMC9928478]. 

MIR136 is a small non-coding RNA molecule that regulates gene expression at the post-transcriptional level. It has been found to be involved in various biological processes, including adipogenesis [PMC9928478]. In the context of preadipocyte differentiation into mature adipocytes, MIR136 levels increase while PPARGC1B expression decreases [PMC9928478'>PMC9928478'>PMC9928478]. 

The role of MIR136 in preadipocyte proliferation and differentiation has been investigated. It is suggested that MIR136 may regulate these processes through its interaction with key transcription factors involved in adipogenesis, such as PPARγ and C/EBPα [PMC9928478]. Additionally, IGF1 may also be involved in the regulatory mechanism of MIR136 during preadipocyte differentiation [PMC9928478].

In summary, MIR136 is a microRNA that plays a role in regulating preadipocyte proliferation and differentiation. Its expression increases during adipogenesis while PPARGC1B levels decrease. The regulatory mechanism involves interactions with key transcription factors such as PPARγ and C/EBPα as well as potential involvement of IGF1 [PMC9928478].

Literature search
73 open access papers mention hsa-mir-136
(354 sentences)


14705 reads, 338 reads per million, 101 experiments

u        g        C     UUU          uuc 
 gagcccuc gaggACUC AUUUG   UGAUGAUGGA   u
 |||||||| |||||||| |||||   ||||||||||   u
 cuugggag cuUCUGAG UAAAC   GCUACUACcu   a
u        a        -     UCU          cgu 

Annotation confidence High
Do you think this miRNA is real?
miR-136 was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2].

Genome context
chr14: 100884702-100884783 [+]
Clustered miRNAs
5 other miRNAs are < 10 kb from hsa-mir-136
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-136 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-136-5p

Accession MIMAT0000448
Description Homo sapiens hsa-miR-136-5p mature miRNA
Evidence experimental
cloned [2-4]
Database links
Predicted targets

Mature hsa-miR-136-3p

Accession MIMAT0004606
Description Homo sapiens hsa-miR-136-3p mature miRNA
Evidence experimental
cloned [4]
Database links
Predicted targets


  1. PubMed ID: 15183728
    Human embryonic stem cells express a unique set of microRNAs
    "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
    "Dev Biol (2004) 270:488-498

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  4. PubMed ID: 15891114
    Clustering and conservation patterns of human microRNAs
    "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
    "Nucleic Acids Res (2005) 33:2697-2706