Stem-loop hsa-mir-136

Accession

MI0000475

Symbol

HGNC: MIR136

Description

Homo sapiens hsa-mir-136 precursor miRNA mir-136

Gene
family

RF00687; mir-136

Literature search

73 open access papers mention hsa-mir-136
(354 sentences)

Sequence

14705 reads, 89 reads per million, 101 experiments

ugagcccucggaggACUCCAUUUGUUUUGAUGAUGGAuucuuaugcucCAUCAUCGUCUCAAAUGAGUCUucagaggguucu
.((((((((.((((((((.(((((...((((((((((.........))))))))))...))))))))))))).)))))))).

Structure

u        g        C     UUU          uuc 
 gagcccuc gaggACUC AUUUG   UGAUGAUGGA   u
 |||||||| |||||||| |||||   ||||||||||   u
 cuugggag cuUCUGAG UAAAC   GCUACUACcu   a
u        a        -     UCU          cgu 

Annotation confidence High

Comments

miR-136 was first identified by cloning studies in mouse [1]. Its expression was later verified in human embryonic stem cells [2].

Genome context

chr14: 100884702-100884783 [+]

Clustered miRNAs

5 other miRNAs are < 10 kb from hsa-mir-136

Disease association

hsa-mir-136 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-136-5p

• Accession: MIMAT0000448
• Description: Homo sapiens hsa-miR-136-5p mature miRNA
• Sequence: 15 - ACUCCAUUUGUUUUGAUGAUGGA - 37
• Evidence: experimental ; cloned [2-4]

Mature hsa-miR-136-3p

• Accession: MIMAT0004606
• Description: Homo sapiens hsa-miR-136-3p mature miRNA
• Sequence: 49 - CAUCAUCGUCUCAAAUGAGUCU - 70
• Evidence: experimental ; cloned [4]

References

1. PubMed ID: 15183728
   Human embryonic stem cells express a unique set of microRNAs
   "Suh MR, Lee Y, Kim JY, Kim SK, Moon SH, Lee JY, Cha KY, Chung HM, Yoon HS, Moon SY, Kim VN, Kim KS"
   "Dev Biol (2004) 270:488-498


2. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


3. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739


4. PubMed ID: 15891114
   Clustering and conservation patterns of human microRNAs
   "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
   "Nucleic Acids Res (2005) 33:2697-2706