miRBase entry: hsa-mir-146a

Stem-loop hsa-mir-146a

Homo sapiens hsa-mir-146a precursor miRNA
Gene family
MIPF0000103; mir-146

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR146A is a microRNA that has been studied in various contexts [PMC10110697]. It has been shown to play a role in chondrogenesis [PMC10110697]. Additionally, MIR146A has been found to have a protective role in diabetic nephropathy [PMC5354466]. The effects of MIR146A are likely mediated by downstream targets, including CNP-MIR146A [PMC10129905]. The binding sites of MIR146A have been analyzed in the intergenic region [PMC6050289]. MIR146A has also been found to enhance the expression and activation of STAT1, which is a direct target of MIR146A [PMC9125934]. The expression and role of MIR146A are unclear in several cancers, including colon cancer [PMC3985145]. The oxidation of MIR146A has been measured using area under the curve measurements [PMC9766199]. Overexpression of pre-MIR146A resulted in increased expression in HEK293 cells [PMC6050289]. Interference with endogenous MIR146A using a miR146-sponge plasmid was done in HBV-carrying mice [PMC4876503]. Engineered exosomes have been suggested as a possible solution for controlling the expression of MIR146A for therapeutic purposes [PMC9922687].

Mice lacking Apoe have shown increased susceptibility to atherosclerosis due to the control exerted by Apoe on the expression of MIR146A [PMC6023389]. Decreased expression levels of MIR145 and MIRA6 were associated with 5q- myelodysplastic syndrome (MDS) deletion syndrome and distant metastases among gastric cancer patients, respectively [PMC4926477] [PMC6778823]. Serum levels of miR-155, miR19a, miR20a, miR30a-3p were also found to be differentially expressed among patients with graft-versus-host disease (GVHD) compared to healthy controls [PMC8170404]. Serum levels were measured pre-transplant and two weeks after hematopoietic cell transplantation (HCT) [PMC8170404]. Serum MIR146A was significantly reduced in esophageal squamous-cell cancer (ESCC) patients [PMC6301302]. MIR146A has been found to be a potential target in mesenchymal stem cell (MSC)-based osteoarthritis (OA) therapy [PMC10110697]. The interaction of MIR146A with predicted sites and the subsequent repression of FANCM has been confirmed using a 3'UTR luciferase reporter assay [PMC5216775]. MIR146A has been shown to be a dominant negative regulator of NFκB by suppressing TRAF6 and activating IKK and NFκB [PMC6651735]. The function of MIR146A differs during the demyelination vs. remyelination process, with continuous infusion of miR-146a mimics promoting remyelination by suppressing inflammatory microglial activation [PMC7468479]. In human T cells, MIR146A is expressed at low levels in naïve T lymphocytes and is induced upon TCR stimulation, consistent with its expression being dependent on NF-κB induction [PMC4641946]. Finally, MIR146A, miR34a, and miR-126 have been found to participate in the inflammatory response after brain injury [PMC8109138].

Literature search
749 open access papers mention hsa-mir-146a
(6781 sentences)


319175 reads, 1682 reads per million, 137 experiments

c     -----u      u     uU            C  U     g  uc 
 cgaug      guaucc cagcu  GAGAACUGAAUU CA GGGUU ug  a
 |||||      |||||| |||||  |||||||||||| || ||||| ||  g
 gcuac      uauagg gucGA  UUCUUGACUUAA GU UCCag ac  u
u     ugucuc      -     -C            A  C     -  ug 

Annotation confidence High
Do you think this miRNA is real?
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. Its expression was later verified in human [2,3].

Genome context
chr5: 160485352-160485450 [+]

Disease association
hsa-mir-146a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-146a-5p

Accession MIMAT0000449
Description Homo sapiens hsa-miR-146a-5p mature miRNA
Evidence experimental
cloned [2-3]
Database links
Predicted targets

Mature hsa-miR-146a-3p

Accession MIMAT0004608
Description Homo sapiens hsa-miR-146a-3p mature miRNA
Evidence experimental
cloned [3]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12007417
    Identification of tissue-specific microRNAs from mouse
    "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
    "Curr Biol (2002) 12:735-739

  3. PubMed ID: 15800047
    Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
    "Cai X, Lu S, Zhang Z, Gonzalez CM, Damania B, Cullen BR"
    "Proc Natl Acad Sci U S A (2005) 102:5570-5575