Stem-loop hsa-mir-150

Accession

MI0000479

Symbol

HGNC: MIR150

Description

Homo sapiens hsa-mir-150 precursor miRNA mir-150

Gene
family

RF00767; mir-150

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR150 is a microRNA implicated in various cellular processes and disease mechanisms. Studies have shown that MYC can regulate MIR150 expression through direct transcriptional activation and post-transcriptional mechanisms, although evidence from chronic myeloid leukemia (CML) cells did not support the repression of miR-150 maturation following BCR-ABL1 inhibition [PMC6269310]. Additionally, the expression of MIR150 is dynamically regulated in T lymphocytes, with a significant reduction observed 24 hours after stimulation, indicating a potential role in the direct control of its expression [PMC8865640]. In the context of hematopoietic cell transplantation (HCT), MIR150 has been identified among various miRNAs in plasma/serum with potential prognostic significance for graft-versus-host disease (GVHD) [PMC9720327]. Furthermore, MIR150 is among the non-coding RNAs from liver tumors that contribute to macrophage polarization, highlighting its role in cell signaling and immune response modulation [PMC9648394].

Literature search

317 open access papers mention hsa-mir-150
(2132 sentences)

Sequence

58970 reads, 1228 reads per million, 108 experiments

cuccccauggcccugUCUCCCAACCCUUGUACCAGUGcugggcucagaccCUGGUACAGGCCUGGGGGACAGggaccuggggac
.((((((.((((((((((((((..(((.(((((((.((((....))).).))))))))))..)))))))))))).)))))))).

Structure

c      u  -            AC   U       U -   g 
 ucccca gg cccugUCUCCCA  CCU GUACCAG G cug g
 |||||| || ||||||||||||  ||| ||||||| | |||  
 aggggu cc ggGACAGGGGGU  GGA CAUGGUC c gac c
c      -  a            CC   -       c a   u 

Annotation confidence High

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context

chr19: 49500785-49500868 [-]

Disease association

hsa-mir-150 is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-150 is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-150 is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-150-5p

• Accession: MIMAT0000451
• Description: Homo sapiens hsa-miR-150-5p mature miRNA
• Sequence: 16 - UCUCCCAACCCUUGUACCAGUG - 37
• Evidence: experimental ; cloned [2]

Mature hsa-miR-150-3p

• Accession: MIMAT0004610
• Description: Homo sapiens hsa-miR-150-3p mature miRNA
• Sequence: 51 - CUGGUACAGGCCUGGGGGACAG - 72
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12007417
   Identification of tissue-specific microRNAs from mouse
   "Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T"
   "Curr Biol (2002) 12:735-739