MIR150 is a microRNA implicated in various cellular processes and disease mechanisms. Studies have shown that MYC can regulate MIR150 expression through direct transcriptional activation and post-transcriptional mechanisms, although evidence from chronic myeloid leukemia (CML) cells did not support the repression of miR-150 maturation following BCR-ABL1 inhibition [PMC6269310]. Additionally, the expression of MIR150 is dynamically regulated in T lymphocytes, with a significant reduction observed 24 hours after stimulation, indicating a potential role in the direct control of its expression [PMC8865640]. In the context of hematopoietic cell transplantation (HCT), MIR150 has been identified among various miRNAs in plasma/serum with potential prognostic significance for graft-versus-host disease (GVHD) [PMC9720327]. Furthermore, MIR150 is among the non-coding RNAs from liver tumors that contribute to macrophage polarization, highlighting its role in cell signaling and immune response modulation [PMC9648394].
c u - AC U U - g ucccca gg cccugUCUCCCA CCU GUACCAG G cug g |||||| || |||||||||||| ||| ||||||| | ||| aggggu cc ggGACAGGGGGU GGA CAUGGUC c gac c c - a CC - c a u
Disease | Description | Category | PubMed ID |
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Accession | MIMAT0000451 |
Description | Homo sapiens hsa-miR-150-5p mature miRNA |
Sequence | 16 - UCUCCCAACCCUUGUACCAGUG - 37 |
Evidence |
experimental
cloned [2] |
Database links |
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Predicted targets |
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Accession | MIMAT0004610 |
Description | Homo sapiens hsa-miR-150-3p mature miRNA |
Sequence | 51 - CUGGUACAGGCCUGGGGGACAG - 72 |
Evidence |
experimental
cloned [2] |
Database links |
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Predicted targets |
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