Stem-loop hsa-mir-184

Accession

MI0000481

Symbol

HGNC: MIR184

Description

Homo sapiens hsa-mir-184 precursor miRNA

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

WARNING: This summary was generated by AI. MIR184 is a microRNA implicated in the regulation of gene expression, and its genetic mutations have been identified in a limited number of genes associated with various diseases [PMC9025197]. In the context of hepatocellular carcinoma (HCC), MIR184 is among several oncogenic microRNAs (OncomiRs) that exhibit significant changes in expression profiles, suggesting a potential role in the pathogenesis or progression of this type of cancer [PMC9741442].

Literature search

338 open access papers mention hsa-mir-184
(1642 sentences)

Sequence

92089 reads, 152.0 reads per million, 142 experiments

ccagucacguccCCUUAUCACUUUUCCAGCCCAGCuuugugacuguaaguguUGGACGGAGAACUGAUAAGGGUaggugauuga
.(((((((.(.(((((((((.((((((.(.(((((((((......)))).))))).))))))).))))))))).).))))))).

Structure

c       g c         C      A C     -    ug 
 cagucac u cCCUUAUCA UUUUCC G CCAGC uuug  a
 ||||||| | ||||||||| |||||| | ||||| ||||   
 guuagug a GGGAAUAGU AAGAGG C GGUug gaau  c
a       g U         C      - A     u    gu 

Annotation confidence High

Comments

This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context

chr15: 79209788-79209871 [+]

Disease association

hsa-mir-184 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-184-5p

• Accession: MIMAT0050494
• Description: Homo sapiens hsa-miR-184-5p mature miRNA
• Sequence: 13 - CCUUAUCACUUUUCCAGCCCAGC - 35
• Evidence: experimental ; cloned [2]

Mature hsa-miR-184-3p

• Accession: MIMAT0000454
• Description: Homo sapiens hsa-miR-184-3p mature miRNA
• Sequence: 53 - UGGACGGAGAACUGAUAAGGGU - 74
• Evidence: experimental ; cloned [2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 12554859
   New microRNAs from mouse and human
   "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
   "RNA (2003) 9:175-179