Accession
MI0000482
Symbol
HGNC:
MIR185
Description
Homo sapiens
hsa-mir-185 precursor miRNA
Gene family
MIPF0000202;
mir-185
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR185 is a microRNA that has been studied in various contexts. In fibrotic livers, an in-situ hybridization assay of MIR185 in human liver fibrotic samples was performed to examine its histological distribution [PMC5039723]. MIR185 is one of the two miRNAs conserved in mice, the other being MIR1306 [PMC4487986]. It has been shown that MIR185 targets ARID1A using miRNA mimics and inhibitors [PMC8367751]. In a study on lung, low dose celecoxib was found to modulate the expression of miR-296 and miR-551b (upregulation) and downregulate the expression of MIR185 [PMC6154745]. Elevated levels of MIR185 were associated with high vascular endothelial growth factor receptor 2 (VEGFR) expression and pro-angiogenic activity in ccRCC [PMC7048408]. However, there is no firm evidence of alteration of miR-185 levels and SNP in MIR185 associated with schizophrenia in humans [PMC8307070]. In mice, low levels of MIR185 in B cells were found to lead to high titers of autoreactive antibodies and autoimmune features [PMC3956820]. Additionally, a study suggested that MIR185 controls the expression of Golgi-apparatus related genes including a new inhibitor of neuronal maturation [PMC3828562].
Literature search
118 open access papers mention hsa-mir-185
(783 sentences)
(783 sentences)
Sequence
507017
reads,
2631
reads per million, 140 experiments
agggggcgagggauUGGAGAGAAAGGCAGUUCCUGAugguccccuccccAGGGGCUGGCUUUCCUCUGGUCcuucccuccca
.(((((.((((((((((((.(((((.(((((((((..((......)).))))))))).))))))))))))))))).))))).
.(((((.((((((((((((.(((((.(((((((((..((......)).))))))))).))))))))))))))))).))))).
Structure
a c A G Au uc ggggg gagggauUGGAG GAAAG CAGUUCCUG gg c ||||| |||||||||||| ||||| ||||||||| || cccuc cuucCUGGUCUC CUUUC GUCGGGGAc cc c a c - G -c uc
Annotation confidence
High
Do you think this miRNA is real?
Comments
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1]. Its expression was later verified in human BC-1 cells [2]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].
Genome context
chr22: 20033139-20033220 [+]
Disease association
hsa-mir-185 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-185-5p
| Accession | MIMAT0000455 |
| Description | Homo sapiens hsa-miR-185-5p mature miRNA |
| Sequence | 15 - UGGAGAGAAAGGCAGUUCCUGA - 36 |
| Evidence |
experimental
cloned [2-4], Illumina [5] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-185-3p
| Accession | MIMAT0004611 |
| Description | Homo sapiens hsa-miR-185-3p mature miRNA |
| Sequence | 50 - AGGGGCUGGCUUUCCUCUGGUC - 71 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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