miRBase entry: hsa-mir-190a

Stem-loop hsa-mir-190a

Homo sapiens hsa-mir-190a precursor miRNA
Gene family
MIPF0000076; mir-190

Caution, this is an AI generated summary based on literature. This may have errors. ?

In a study, it has been observed that there are different miRNA expressions between GF and colonized animals, specifically involving the CREB and Ras/MAPK pathways, with a significant role of MIR190A in the MGB axis [PMC8615526]. The downregulation of miRNAs involved in extracellular matrix remodeling, including MIR190A, has been linked to the early onset of fibrosis in double-infected transplanted livers [PMC8869900]. MIR190A has been shown to facilitate bladder cancer invasion and autophagy by stabilizing ATG7 mRNA through binding to its 3′UTR [PMC8514698]. The binding of MIR190A to the 3′-UTR of ATG7 mRNA has also been demonstrated in humans [PMC7226452]. Plasmids targeting ATG7, HNRNPD, and MIR190A were used in experiments [PMC6468970]. Ectopic expression of MIR190A promoted invasion of UMUC3 cells, while control expression did not have an effect on invasion [PMC6468970]. The study provided evidence supporting MIR190A as a critical mediator for ATG7 mRNA stabilization in human bladder cancer cells [PMC6468970]. The activity of ATG7 3′-UTR luciferase reporter was significantly increased by ectopic expression of MIR190A and inhibited by antisense targeting MIR190A [PMC6468970'>PMC6468970'>PMC6468970'>PMC6468970'>PMC6468970]. HNRNPD and ARHGDIB expressions were consistently observed in tumors obtained from xenograft nude mice injected with UMUC3 cells expressing different constructs [PMC6468970]. The inhibition or induction of autophagy had an effect on HNRNPD and ARHGDIB expression in UMUC3 cells expressing ectopic or antisense forms of MIR190A [PMC6468970]. Deficiency of MIR190A expression increased PHLPP1 protein expression and impaired ATG7 protein expression [PMC6468970]. MIR190A has been found to promote bladder cancer invasion and autophagy by stabilizing ATG7 mRNA [PMC6468970]. The upregulation of MIR190A has been observed in human bladder cancer tissues [PMC6468970].

Literature search
43 open access papers mention hsa-mir-190a
(214 sentences)


8022 reads, 127 reads per million, 94 experiments

u     c u     -U                UA     uuau 
 gcagg c cugug  GAUAUGUUUGAUAUAU  GGUug    u
 ||||| | |||||  ||||||||||||||||  |||||     
 cguuc g gacaU  UUAUACAAACUAUAUA  UCaac    u
c     u u     CC                --     cuaa 

Annotation confidence High
Do you think this miRNA is real?
This miRNA sequence is predicted based on homology to a verified miRNA from mouse [1], later verified in human [2].

Genome context
chr15: 62823957-62824041 [+]

Disease association
hsa-mir-190a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-190a-5p

Accession MIMAT0000458
Description Homo sapiens hsa-miR-190a-5p mature miRNA
Evidence experimental
cloned [2], Illumina [3]
Database links
Predicted targets

Mature hsa-miR-190a-3p

Accession MIMAT0026482
Description Homo sapiens hsa-miR-190a-3p mature miRNA
Evidence experimental
Illumina [3]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 12554859
    New microRNAs from mouse and human
    "Lagos-Quintana M, Rauhut R, Meyer J, Borkhardt A, Tuschl T"
    "RNA (2003) 9:175-179

  3. PubMed ID: 23034410
    Birth and expression evolution of mammalian microRNA genes
    "Meunier J, Lemoine F, Soumillon M, Liechti A, Weier M, Guschanski K, Hu H, Khaitovich P, Kaessmann H"
    "Genome Res (2013) 23:34-45