Stem-loop rno-mir-346

Accession

MI0000633

Description

Rattus norvegicus rno-mir-346 precursor miRNA

Literature search

30 open access papers mention rno-mir-346
(109 sentences)

Sequence

24419 reads, 46.0 reads per million, 244 experiments

ucuguguugggcaucUGUCUGCCUGAGUGCCUGCCUCUcuguugcucugaaggAGGCAGGGGCUGGGCCUGCAGCUGccugggcagagcugcuccuuc
(((((..((((((.((((..((((.(((.((((((((.((..........)))))))))).)))))))..)))).)))))).)))))...........

Structure

-----------     gu      u    CU    G   G        U  guug 
           ucugu  ugggca cUGU  GCCU AGU CCUGCCUC cu    c
           |||||  |||||| ||||  |||| ||| |||||||| ||     
           agacg  guccGU GACG  CGGG UCG GGACGGAg ga    u
cuuccucgucg     -g      C    UC    -   G        -  aguc 

Annotation confidence High

Comments

Kim et al. cloned 40 new miRNAs from rat E18 primary cortical neurons [1]. The sequence reported in [1] contains two 3' terminal A residues, which conflict with the precursor sequence shown here.

Genome context

chr16: 11250054-11250151 [+]

Mature rno-miR-346-5p

• Accession: MIMAT0000596
• Description: Rattus norvegicus rno-miR-346-5p mature miRNA
• Sequence: 16 - UGUCUGCCUGAGUGCCUGCCUCU - 38
• Evidence: experimental ; cloned [1-2], SOLiD [3]

Mature rno-miR-346-3p

• Accession: MIMAT0052017
• Description: Rattus norvegicus rno-miR-346-3p mature miRNA
• Sequence: 54 - AGGCAGGGGCUGGGCCUGCAGCUG - 77
• Evidence: experimental ; cloned [1-2], SOLiD [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365


3. PubMed ID: 20403161
   Small RNA expression and strain specificity in the rat
   Linsen SE, de Wit E, de Bruijn E, Cuppen E
   BMC Genomics (2010) 11:249