Stem-loop rno-mir-7a-1

Accession

MI0000641

Description

Rattus norvegicus rno-mir-7a-1 precursor miRNA

Literature search

43 open access papers mention rno-mir-7a-1
(248 sentences)

Sequence

52275 reads, 39 reads per million, 481 experiments

uguuggccuaguucugugUGGAAGACUAGUGAUUUUGUUGUuuuuagauaacuaagacgACAACAAAUCACAGUCUGCCAUauggcacaggccaccu
...((((((.((.((((((((.(((((.(((((((.(((((((((((....)))))..)))))))))))))))))).)))))))).))))))))...

Structure

ugu      a  u        A     A       U      --     a 
   uggccu gu cugugUGG AGACU GUGAUUU GUUGUu  uuuag u
   |||||| || |||||||| ||||| ||||||| ||||||  |||||  
   accgga ca gguaUACC UCUGA CACUAAA CAACAg  gaauc a
ucc      -  c        G     -       -      ca     a 

Annotation confidence High

Comments

Landgraf et al. show that the 5' product is the predominant one [3]. The 3' product is renamed miR-7a*. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3]. The ends of the miRNA may be offset with respect to previous annotations.

Genome context

chr17: 6675016-6675112 [+]

Mature rno-miR-7a-1-3p

• Accession: MIMAT0000607
• Description: Rattus norvegicus rno-miR-7a-1-3p mature miRNA
• Sequence: 60 - ACAACAAAUCACAGUCUGCCAU - 81
• Evidence: experimental ; cloned [1,3], Northern [1], SOLiD [4]

Mature rno-miR-7a-5p

• Accession: MIMAT0000606
• Description: Rattus norvegicus rno-miR-7a-5p mature miRNA
• Sequence: 19 - UGGAAGACUAGUGAUUUUGUUGU - 41
• Evidence: experimental ; cloned [1-2], SOLiD [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365


3. PubMed ID: 20403161
   Small RNA expression and strain specificity in the rat
   Linsen SE, de Wit E, de Bruijn E, Cuppen E
   BMC Genomics (2010) 11:249


4. PubMed ID: 15345052
   Microarray analysis of microRNA expression in the developing mammalian brain
   Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
   Genome Biol (2004) 5:R68