Accession
MI0000738
Symbol
HGNC:
MIR302A
Description
Homo sapiens
hsa-mir-302a precursor miRNA mir-302
Gene
family?
family?
RF00668;
mir-302
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR302A is a microRNA involved in various cellular processes, including the regulation of inflammation, oxidative stress, and cell proliferation [PMC7576609; PMC8685359; PMC9889149].. It is part of the miR-302/367 cluster, which is highly expressed in embryonic stem cells and plays a role in stem cell formation and differentiation [PMC6722449]. MIR302A expression has been associated with the regulation of genes involved in cancer progression and has potential as a biomarker for tumor characteristics in colorectal cancer [PMC7602903]. It can also regulate gene expression by directly binding to target mRNA sequences, as demonstrated with ZFP91-3′UTR in luciferase reporter assays [PMC8365611]. Dysregulation of MIR302A has been implicated in various diseases including cancer, where it can act as both an oncogene and tumor suppressor gene [PMC4430936; PMC4761210].'>PMC4761210].. Moreover, MIR302A expression is modulated during cellular differentiation processes such as adipogenesis and osteogenesis [PMC4951121], and it can influence cell viability through signaling pathways like MAPK [PMC8612787]. Research also indicates that MIR302A may be involved in microvesicle-mediated miRNA transfer and NF-κB signaling pathway dysfunction during hepatocarcinogenesis [PMC4761210].
Literature search
193 open access papers mention hsa-mir-302a
(1105 sentences)
(1105 sentences)
Sequence
1300
reads,
362
reads per million, 16 experiments
ccaccACUUAAACGUGGAUGUACUUGCUuugaaacuaaagaagUAAGUGCUUCCAUGUUUUGGUGAugg
(((.((((.(((((((((.(((((((((((.........))))))))))).))))))))).)))).)))
(((.((((.(((((((((.(((((((((((.........))))))))))).))))))))).)))).)))
Structure
c U U gaa cca cACU AAACGUGGA GUACUUGCUuu a ||| |||| ||||||||| ||||||||||| c ggu GUGG UUUGUACCU CGUGAAUgaag u A U U aaa
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr4: 112648183-112648251 [-]
Clustered miRNAs
4 other miRNAs are < 10 kb from hsa-mir-302a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Biological pathways
hsa-mir-302a is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-302a is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-302a-5p
| Accession | MIMAT0000683 |
| Description | Homo sapiens hsa-miR-302a-5p mature miRNA |
| Sequence | 6 - ACUUAAACGUGGAUGUACUUGCU - 28 |
| Evidence |
experimental
cloned [2,4], Northern [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-302a-3p
| Accession | MIMAT0000684 |
| Description | Homo sapiens hsa-miR-302a-3p mature miRNA |
| Sequence | 44 - UAAGUGCUUCCAUGUUUUGGUGA - 66 |
| Evidence |
experimental
cloned [2,4], Northern [2] |
| Database links |
|
| Predicted targets |
|
References
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