Accession
MI0000738
Symbol
HGNC:
MIR302A
Description
Homo sapiens
hsa-mir-302a precursor miRNA mir-302
Gene
family?
family?
RF00668;
mir-302
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR302A is a microRNA that is part of the miR-302 family, which includes MIR302B, MIR302C, and MIR302D [PMC5906557]. It is highly expressed in embryonic stem cells but declines rapidly after differentiation [PMC6722449]. MIR302A has been shown to be involved in various biological processes and diseases. For example, it has been found to be associated with the inhibition of EC migration and proliferation in end-stage renal disease [PMC8685359]. In addition, dysregulation of MIR302A has been implicated in hepatocarcinogenesis and contributes to microvesicle-mediated transfer of miRNAs and dysfunction of the NF-κB signaling pathway [PMC4761210]. Furthermore, MIR302A has been shown to regulate the expression of p65 by binding with ZFP91 directly [PMC8365611]. It has also been found to be related to tumor size and metastasis in colorectal cancer patients [PMC7602903]. Moreover, overexpression of miR-302s (including MIR302A) induces apoptosis in cancer cell lines [PMC4400607]. Overall, MIR302A plays a crucial role in various biological processes and diseases through its regulation of gene expression.
Literature search
193 open access papers mention hsa-mir-302a
(1105 sentences)
(1105 sentences)
Sequence
1300
reads,
362
reads per million, 16 experiments
ccaccACUUAAACGUGGAUGUACUUGCUuugaaacuaaagaagUAAGUGCUUCCAUGUUUUGGUGAugg
(((.((((.(((((((((.(((((((((((.........))))))))))).))))))))).)))).)))
(((.((((.(((((((((.(((((((((((.........))))))))))).))))))))).)))).)))
Structure
c U U gaa cca cACU AAACGUGGA GUACUUGCUuu a ||| |||| ||||||||| ||||||||||| c ggu GUGG UUUGUACCU CGUGAAUgaag u A U U aaa
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chr4: 112648183-112648251 [-]
Clustered miRNAs
4 other miRNAs are < 10 kb from hsa-mir-302a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Biological pathways
hsa-mir-302a is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-302a is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-302a-5p
| Accession | MIMAT0000683 |
| Description | Homo sapiens hsa-miR-302a-5p mature miRNA |
| Sequence | 6 - ACUUAAACGUGGAUGUACUUGCU - 28 |
| Evidence |
experimental
cloned [2,4], Northern [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-302a-3p
| Accession | MIMAT0000684 |
| Description | Homo sapiens hsa-miR-302a-3p mature miRNA |
| Sequence | 44 - UAAGUGCUUCCAUGUUUUGGUGA - 66 |
| Evidence |
experimental
cloned [2,4], Northern [2] |
| Database links |
|
| Predicted targets |
|
References
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