miRBase entry: hsa-mir-101-2

Stem-loop hsa-mir-101-2


Accession
MI0000739
Symbol
HGNC: MIR101-2
Description
Homo sapiens hsa-mir-101-2 precursor miRNA
Gene family
MIPF0000046; mir-101

Literature search
307 open access papers mention hsa-mir-101-2
(2269 sentences)

Sequence

1193067 reads, 3835 reads per million, 140 experiments
acuguccuuuuUCGGUUAUCAUGGUACCGAUGCuguauaucugaaaggUACAGUACUGUGAUAACUGAAgaaugguggu
((((.((((((((((((((((((((((.(.((((............))))).)))))))))))))))))))).))))))

Structure
    u  -                    C A    guaua 
acug cc uuuuUCGGUUAUCAUGGUAC G UGCu     u
|||| || |||||||||||||||||||| | ||||      
uggu gg aagAAGUCAAUAGUGUCAUG C AUgg     c
    -  u                    A -    aaagu 


Annotation confidence High
Do you think this miRNA is real?
Comments
Reference [1] reports two miR-101 precursor hairpin structures in human, on chromosome 1 (MIR:MI0000103) and 9 (MIR:MI0000739, named mir-101-precursor-9 in [1]). The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context
chr9: 4850297-4850375 [+]

Disease association
hsa-mir-101-2 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID


Database links

Mature hsa-miR-101-3p

Accession MIMAT0000099
Description Homo sapiens hsa-miR-101-3p mature miRNA
Sequence 49 - UACAGUACUGUGAUAACUGAA - 69
Evidence experimental
cloned [1-4]
Database links
Predicted targets

Mature hsa-miR-101-2-5p

Accession MIMAT0037312
Description Homo sapiens hsa-miR-101-2-5p mature miRNA
Sequence 12 - UCGGUUAUCAUGGUACCGAUGC - 33
Evidence not_experimental

References

  1. PubMed ID: 15325244
    Altered expression profiles of microRNAs during TPA-induced differentiation of HL-60 cells
    "Kasashima K, Nakamura Y, Kozu T"
    "Biochem Biophys Res Commun (2004) 322:403-410

  2. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  3. PubMed ID: 17616659
    Patterns of known and novel small RNAs in human cervical cancer
    "Lui WO, Pourmand N, Patterson BK, Fire A"
    "Cancer Res (2007) 67:6031-6043

  4. PubMed ID: 11914277
    miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs
    "Mourelatos Z, Dostie J, Paushkin S, Sharma A, Charroux B, Abel L, Rappsilber J, Mann M, Dreyfuss G"
    "Genes Dev (2002) 16:720-728