Accession
MI0000760
Symbol
HGNC:
MIR361
Description
Homo sapiens
hsa-mir-361 precursor miRNA mir-361
Gene
family?
family?
RF00744;
mir-361
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR361 is a gene encoding a microRNA located on the X chromosome, specifically in an intron between exons 9 and 10 of the CHM gene, and it produces two mature miRNA species, miR-361-3p and the more predominant miR-361-5p [PMC3498195]. The transcription of MIR361 is negatively regulated by SMAD4, which binds to the MIR361 promoter and functions as a trans-acting element to adjust VEGFA expression by negatively regulating MIR361 transcription [PMC7563248]. This regulatory relationship was further confirmed through luciferase reporter assays which demonstrated SMAD4's inhibitory effect on MIR361 promoter activity [PMC7563248]. Additionally, MIR361 expression is influenced by the TGF-β signaling pathway [PMC7563248], and it has been identified as differentially expressed in various physiological states such as pregnancy, where it was found to be upregulated in women during the first and third trimesters [PMC9700700]. Moreover, MIR361 has been implicated as a tumor suppressor in endometrial cancers when downregulated [PMC8369952], suggesting its potential role in tumorigenesis. In cardiovascular contexts, increased serum levels of MIR361 have been associated with heart failure (HF) and major adverse cardiac events (MACE) [PMC9967129].
Literature search
63 open access papers mention hsa-mir-361
(430 sentences)
(430 sentences)
Sequence
85647
reads,
697
reads per million, 146 experiments
ggagcUUAUCAGAAUCUCCAGGGGUACuuuauaauuucaaaaagUCCCCCAGGUGUGAUUCUGAUUUgcuuc
(((((..(((((((((.((.((((.(((((..........))))).)))).))...)))))))))..)))))
(((((..(((((((((.((.((((.(((((..........))))).)))).))...)))))))))..)))))
Structure
UU --U A U auaa
ggagc AUCAGAAUC CC GGGG ACuuu u
||||| ||||||||| || |||| |||||
cuucg UAGUCUUAG GG CCCC Ugaaa u
UU UGU A C aacu
Annotation confidence
High
Do you think this miRNA is real?
Genome context
chrX: 85903636-85903707 [-]
Disease association
hsa-mir-361 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-361-5p
| Accession | MIMAT0000703 |
| Description | Homo sapiens hsa-miR-361-5p mature miRNA |
| Sequence | 6 - UUAUCAGAAUCUCCAGGGGUAC - 27 |
| Evidence |
experimental
cloned [2] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-361-3p
| Accession | MIMAT0004682 |
| Description | Homo sapiens hsa-miR-361-3p mature miRNA |
| Sequence | 45 - UCCCCCAGGUGUGAUUCUGAUUU - 67 |
| Evidence |
experimental
cloned [2-3], Northern [3] |
| Database links |
|
| Predicted targets |
|
References
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