Accession
MI0000769
Symbol
HGNC:
MIR365B
Description
Homo sapiens
hsa-mir-365b precursor miRNA
Gene family
MIPF0000061;
mir-365
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR365B is a microRNA gene located within the NF1 microdeletion region, which is associated with neurofibromatosis type 1 (NF1) and tumorigenesis [PMC5370280]. Patients with NF1 microdeletions are hemizygous for MIR365B, along with other genes such as NF1, SUZ12, ATAD5, and MIR193A [PMC5370280]. The loss of MIR193A and MIR365B genes in patients with NF1 microdeletions may contribute to tumorigenesis in these individuals [PMC5370280]. While the role of SUZ12 loss in malignant peripheral nerve sheath tumor (MPNST) progression is well-documented, less is known about the involvement of ATAD5, MIR193A, and MIR365B in MPNST pathogenesis [PMC5370280]. The 1.4-Mb NF1 microdeletion region contains four microRNA genes: MIR193A, MIR365B, MIR4725, and MIR4733 [PMC5370280]. RT-qPCR analysis has been performed to study gene expression using TaqMan assays for validation purposes [PMC8278229]. Several miRNAs including miR-4262, miR-506-3p, and MIR365B have been identified as tumor suppressors targeting GALNT4 [PMC8504460]. Drosha cleavage activity has been detected over intronic regions of genes such as CTDSP1 and long noncoding RNA (lncRNA)-derived genes like MIR193A and MIR365B using POINT-5 analysis [PMC8122139]. ATAD5 along with other genes like miR193A and miR365B have been identified as having tumor suppressor activity within the NF1 microdeletion region [PMC8395254].
Literature search
61 open access papers mention hsa-mir-365b
(319 sentences)
(319 sentences)
Sequence
83123
reads,
1088
reads per million, 133 experiments
agaguguucaaggacagcaagaaaaaugAGGGACUUUCAGGGGCAGCUGUguuuucugacucagucaUAAUGCCCCUAAAAAUCCUUAUuguucuugcagugugcaucggg
...........(.((((((((((.((((((((..(((.(((((((((((.(((....))).)))).....))))))).))).)))))))).)))))))..))).)......
...........(.((((((((((.((((((((..(((.(((((((((((.(((....))).)))).....))))))).))).)))))))).)))))))..))).)......
Structure
agaguguucaa g -- a AC C ----- U u
g aca gcaagaa aaugAGGG UUU AGGGGCA GCUG guu u
| ||| ||||||| |||||||| ||| ||||||| |||| |||
c ugu cguucuu uUAUUCCU AAA UCCCCGU ugac cag c
-----gggcua g ga g -A A AAUac u u
Annotation confidence
High
Do you think this miRNA is real?
Comments
Xie et al. [1] refer to this sequence by the internal identifier MIR190. The sequence is unrelated to mammalian mir-190 (MIR:MI0000486).
Genome context
chr17: 31575411-31575521 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from hsa-mir-365b
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-365b is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-365b-5p
| Accession | MIMAT0022833 |
| Description | Homo sapiens hsa-miR-365b-5p mature miRNA |
| Sequence | 29 - AGGGACUUUCAGGGGCAGCUGU - 50 |
| Evidence |
experimental
454 [5] |
| Database links |
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| Predicted targets |
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Mature hsa-miR-365b-3p
| Accession | MIMAT0022834 |
| Description | Homo sapiens hsa-miR-365b-3p mature miRNA |
| Sequence | 68 - UAAUGCCCCUAAAAAUCCUUAU - 89 |
| Evidence |
experimental
cloned [1,3-4], array-cloned [2] |
| Database links |
|
| Predicted targets |
|
References
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