Stem-loop hsa-mir-376a-1

Accession

MI0000784

Symbol

HGNC: MIR376A1

Description

Homo sapiens hsa-mir-376a-1 precursor miRNA mir-368

Gene
family

RF04291; mir-368

Literature search

80 open access papers mention hsa-mir-376a-1
(414 sentences)

Sequence

2872 reads, 91 reads per million, 69 experiments

uaaaagGUAGAUUCUCCUUCUAUGAGUAcauuauuuaugauuaAUCAUAGAGGAAAAUCCACGUuuuc
.((((.((.((((.((((.((((((...(((.....))).....)))))))))).)))).)).)))).

Structure

u    g  A    C    U      --GUA   u 
 aaaa GU GAUU UCCU CUAUGA     cau a
 |||| || |||| |||| ||||||     ||| u
 uuuU CA CUAA AGGA GAUACU     gua u
c    G  C    A    -      Aauua   u 

Annotation confidence High

Comments

The mature miR-376a products have been shown to be modified by A to I edits [3].

Genome context

chr14: 101040782-101040849 [+]

Clustered miRNAs

15 other miRNAs are < 10 kb from hsa-mir-376a-1

Disease association

hsa-mir-376a-1 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-376a-5p

• Accession: MIMAT0003386
• Description: Homo sapiens hsa-miR-376a-5p mature miRNA
• Sequence: 7 - GUAGAUUCUCCUUCUAUGAGUA - 28
• Evidence: experimental ; cloned [2,4]

Mature hsa-miR-376a-3p

• Accession: MIMAT0000729
• Description: Homo sapiens hsa-miR-376a-3p mature miRNA
• Sequence: 44 - AUCAUAGAGGAAAAUCCACGU - 64
• Evidence: experimental ; cloned [1,3], SOLiD [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15891114
   Clustering and conservation patterns of human microRNAs
   "Altuvia Y, Landgraf P, Lithwick G, Elefant N, Pfeffer S, Aravin A, Brownstein MJ, Tuschl T, Margalit H"
   "Nucleic Acids Res (2005) 33:2697-2706


3. PubMed ID: 16274478
   Identification of clustered microRNAs using an ab initio prediction method
   Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
   BMC Bioinformatics (2005) 6:267


4. PubMed ID: 17322061
   Redirection of silencing targets by adenosine-to-inosine editing of miRNAs
   "Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K"
   "Science (2007) 315:1137-1140