Accession
MI0000788
Symbol
HGNC:
MIR380
Description
Homo sapiens
hsa-mir-380 precursor miRNA mir-379
Gene
family?
family?
RF04292;
mir-379
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR380 is a microRNA implicated in the regulation of p53 signaling, particularly noted for its role in neuroblastoma where it attenuates this tumor suppressor pathway [PMC8044846]. In the context of multiple myeloma (MM), MIR380, along with miR382, is upregulated in mesenchymal stem cells (MSCs) by HDAC3, which also stimulates the expression of TSG101, a component of the ESCRT complex [PMC8044846]. This upregulation contributes to an increase in MSC-exosome content of MIR380 [PMC8044846]. However, when HDAC3 is knocked down, there is a notable decrease in exosomal expression of MIR380 and other miRNAs associated with pro-survival functions [PMC6883144], leading to cell growth arrest [PMC8392438]. This suggests that MIR380 may play a role in tumor survival and proliferation. Additionally, it has been observed that exosomes from MM cells co-cultured with MSCs exhibit increased levels of pro-survival miRNAs including MIR380 when compared to MM cells alone [PMC6883144], indicating an interaction between MSCs and MM cells that may affect tumor progression.
Literature search
13 open access papers mention hsa-mir-380
(18 sentences)
(18 sentences)
Sequence
1033
reads,
6
reads per million, 53 experiments
aagaUGGUUGACCAUAGAACAUGCGCuaucucugugucgUAUGUAAUAUGGUCCACAUCUU
((((((...(((((((..(((((((.(((....))).)))))))..)))))))..))))))
((((((...(((((((..(((((((.(((....))).)))))))..)))))))..))))))
Structure
GUU GA C c
aagaUG GACCAUA ACAUGCG uau u
|||||| ||||||| ||||||| |||
UUCUAC CUGGUAU UGUAUgc gug c
-AC AA u u
Annotation confidence
High
Do you think this miRNA is real?
Comments
Landgraf et al. confirm that the 3' product is the predominant one [3].
Genome context
chr14: 101025017-101025077 [+]
Clustered miRNAs
12 other miRNAs are < 10 kb from hsa-mir-380
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-380 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-380-5p
| Accession | MIMAT0000734 |
| Description | Homo sapiens hsa-miR-380-5p mature miRNA |
| Sequence | 5 - UGGUUGACCAUAGAACAUGCGC - 26 |
| Evidence | not_experimental |
Mature hsa-miR-380-3p
| Accession | MIMAT0000735 |
| Description | Homo sapiens hsa-miR-380-3p mature miRNA |
| Sequence | 40 - UAUGUAAUAUGGUCCACAUCUU - 61 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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