Accession
MI0000788
Symbol
HGNC:
MIR380
Description
Homo sapiens
hsa-mir-380 precursor miRNA
Gene family
MIPF0000126;
mir-379
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR380 is a microRNA that has been shown to attenuate p53 signaling in neuroblastoma and is transcribed from the maternal chromosome along the Rian extension of the Dlk1-Dio3 imprinted domain [PMC8044846] [PMC3919614]. Inhibitory experiments have demonstrated that HDAC3 plays a regulatory role in mesenchymal stem cells (MSCs) by stimulating the expression of Tumor Susceptibility Gene 101 (TSG101) and increasing the content of MIR380 and miR382 in MSC-derived exosomes [PMC8044846]. miR382 is overexpressed in multiple myeloma (MM) patients and targets tumor suppressor genes involved in tumor proliferation and survival, suggesting a pathogenetic function for this microRNA [PMC8044846] [PMC6883144]. Knockdown of HDAC3 leads to a decrease in exosomal expression of MIR380, miR382, as well as other pro-survival microRNAs such as miR15b, miR9986, and miR5191, resulting in cell growth arrest [PMC8392438] [PMC6883144]. Co-culturing MM cells with HDAC3-expressing cells leads to increased expression of pro-survival microRNAs including MIR380 and miR382 in exosomes derived from MM cells [PMC6883144]. These findings suggest that MIR380 and miR382 may have important roles in regulating cell survival and proliferation, particularly in the context of neuroblastoma and MM.
Literature search
13 open access papers mention hsa-mir-380
(18 sentences)
(18 sentences)
Sequence
1033
reads,
36
reads per million, 53 experiments
aagaUGGUUGACCAUAGAACAUGCGCuaucucugugucgUAUGUAAUAUGGUCCACAUCUU
((((((...(((((((..(((((((.(((....))).)))))))..)))))))..))))))
((((((...(((((((..(((((((.(((....))).)))))))..)))))))..))))))
Structure
GUU GA C c
aagaUG GACCAUA ACAUGCG uau u
|||||| ||||||| ||||||| |||
UUCUAC CUGGUAU UGUAUgc gug c
-AC AA u u
Annotation confidence
High
Do you think this miRNA is real?
Comments
Landgraf et al. confirm that the 3' product is the predominant one [3].
Genome context
chr14: 101025017-101025077 [+]
Clustered miRNAs
12 other miRNAs are < 10 kb from hsa-mir-380
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-380 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-380-5p
| Accession | MIMAT0000734 |
| Description | Homo sapiens hsa-miR-380-5p mature miRNA |
| Sequence | 5 - UGGUUGACCAUAGAACAUGCGC - 26 |
| Evidence | not_experimental |
Mature hsa-miR-380-3p
| Accession | MIMAT0000735 |
| Description | Homo sapiens hsa-miR-380-3p mature miRNA |
| Sequence | 40 - UAUGUAAUAUGGUCCACAUCUU - 61 |
| Evidence |
experimental
cloned [3] |
| Database links |
|
| Predicted targets |
|
References
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