miRBase entry: mmu-mir-376a

Stem-loop mmu-mir-376a

MGI: Mir376a
Mus musculus mmu-mir-376a precursor miRNA
Gene family
MIPF0000091; mir-368

Literature search
32 open access papers mention mmu-mir-376a
(93 sentences)


102591 reads, 1757 reads per million, 76 experiments

u    G  A    C    U      GUacaaua 
 aaaa GU GAUU UCCU CUAUGA        u
 |||| || |||| |||| ||||||        u
 uuuU CA CUAA AGGA GAUGCU        a
c    G  C    A    -      Aaucagua 

Annotation confidence High
Do you think this miRNA is real?
Seitz et al. predicted a cluster of 40 miRNAs in the imprinted human 14q32 domain, and confirmed the expression of a subset by Northern blot or primer extension in mouse [1]. The expression of miR-376a was independently verified by Poy et al. [2]. The mature miR-376a products have been shown to be modified by A to I edits [4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [5].

Genome context
chr12: 109723781-109723848 [+]
Clustered miRNAs
16 other miRNAs are < 10 kb from mmu-mir-376a
Name Accession Chromosome Start End Strand Confidence

Database links

Mature mmu-miR-376a-5p

Accession MIMAT0003387
Description Mus musculus mmu-miR-376a-5p mature miRNA
Evidence experimental
cloned [3,5], Illumina [6-7]
Database links
Predicted targets

Mature mmu-miR-376a-3p

Accession MIMAT0000740
Description Mus musculus mmu-miR-376a-3p mature miRNA
Evidence experimental
Northern [1], PCR [1], cloned [2-3,5], Illumina [6-7]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15538371
    A pancreatic islet-specific microRNA regulates insulin secretion
    "Poy MN, Eliasson L, Krutzfeldt J, Kuwajima S, Ma X, Macdonald PE, Pfeffer S, Tuschl T, Rajewsky N, Rorsman P, Stoffel M"
    "Nature (2004) 432:226-230

  3. PubMed ID: 20215419
    MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
    "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
    "Mol Hum Reprod (2010) 16:463-471

  4. PubMed ID: 20413612
    Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
    "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
    "Genes Dev (2010) 24:992-1009

  5. PubMed ID: 15310658
    A large imprinted microRNA gene cluster at the mouse Dlk1-Gtl2 domain
    "Seitz H, Royo H, Bortolin ML, Lin SP, Ferguson-Smith AC, Cavaille J"
    "Genome Res (2004) 14:1741-1748

  6. PubMed ID: 16274478
    Identification of clustered microRNAs using an ab initio prediction method
    Sewer A, Paul N, Landgraf P, Aravin A, Pfeffer S, Brownstein MJ, Tuschl T, van Nimwegen E, Zavolan M
    BMC Bioinformatics (2005) 6:267

  7. PubMed ID: 17322061
    Redirection of silencing targets by adenosine-to-inosine editing of miRNAs
    "Kawahara Y, Zinshteyn B, Sethupathy P, Iizasa H, Hatzigeorgiou AG, Nishikura K"
    "Science (2007) 315:1137-1140