Stem-loop hsa-mir-340

Accession

MI0000802

Symbol

HGNC: MIR340

Description

Homo sapiens hsa-mir-340 precursor miRNA mir-340

Gene
family

RF00761; mir-340

Literature search

75 open access papers mention hsa-mir-340
(422 sentences)

Sequence

271302 reads, 937 reads per million, 133 experiments

uuguaccuggugugaUUAUAAAGCAAUGAGACUGAUUgucauaugucguuugugggaUCCGUCUCAGUUACUUUAUAGCcauaccugguaucuua
..(((((.((((((.((((((((...((((((.((((.(((((.......))))))))).))))))....)))))))).)))))).)))))....

Structure

--uu     u      a        -CAA      U    g     ug 
    guacc ggugug UUAUAAAG    UGAGAC GAUU ucaua  u
    ||||| |||||| ||||||||    |||||| |||| |||||  c
    uaugg ccauac GAUAUUUC    ACUCUG CUag ggugu  g
auuc     u      C        AUUG      C    -     uu 

Annotation confidence High

Comments

This sequence is the predicted homologue of a miRNA cloned from rat neuronal tissue [1,2]. Landgraf et al. show that the 5' product is the predominant one in human, mouse and rat [3], in contrast to the previous annotation. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [3].

Genome context

chr5: 180015303-180015397 [-]

Disease association

hsa-mir-340 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-340-5p

• Accession: MIMAT0004692
• Description: Homo sapiens hsa-miR-340-5p mature miRNA
• Sequence: 16 - UUAUAAAGCAAUGAGACUGAUU - 37
• Evidence: experimental ; cloned [3]

Mature hsa-miR-340-3p

• Accession: MIMAT0000750
• Description: Homo sapiens hsa-miR-340-3p mature miRNA
• Sequence: 58 - UCCGUCUCAGUUACUUUAUAGC - 79
• Evidence: experimental ; cloned [3]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73


3. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365