Stem-loop hsa-mir-345

Accession

MI0000825

Symbol

HGNC: MIR345

Description

Homo sapiens hsa-mir-345 precursor miRNA mir-345

Gene
family

RF01044; mir-345

Literature search

124 open access papers mention hsa-mir-345
(463 sentences)

Sequence

61900 reads, 144.0 reads per million, 191 experiments

acccaaacccuaggucuGCUGACUCCUAGUCCAGGGCUCgugauggcugguggGCCCUGAACGAGGGGUCUGGAGgccuggguuugaauaucgacagc
...(((((((.((((((.(.(((((((.((.((((((((((........)))))))))).)).))))))).).)))))))))))))............

Structure

---------acc       u      G U       A  C          gau 
            caaaccc aggucu C GACUCCU GU CAGGGCUCgu   g
            ||||||| |||||| | ||||||| || ||||||||||    
            guuuggg uccgGA G CUGGGGA CA GUCCCGggug   g
cgacagcuauaa       -      G U       G  A          guc 

Annotation confidence High

Comments

This sequence is the predicted human homologue [2] of a sequence cloned from rat neuronal tissue [1], later validated in human [3,4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context

chr14: 100307859-100307956 [+]

Disease association

hsa-mir-345 is associated with one or more human diseases in the Human microRNA Disease Database

Mature hsa-miR-345-5p

• Accession: MIMAT0000772
• Description: Homo sapiens hsa-miR-345-5p mature miRNA
• Sequence: 18 - GCUGACUCCUAGUCCAGGGCUC - 39
• Evidence: experimental ; cloned [3-4], Northern [3]

Mature hsa-miR-345-3p

• Accession: MIMAT0022698
• Description: Homo sapiens hsa-miR-345-3p mature miRNA
• Sequence: 54 - GCCCUGAACGAGGGGUCUGGAG - 75
• Evidence: not_experimental

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15978578
   Identification of human fetal liver miRNAs by a novel method
   "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
   "FEBS Lett (2005) 579:3849-3854


3. PubMed ID: 15634332
   New human and mouse microRNA genes found by homology search
   "Weber MJ"
   "FEBS J (2005) 272:59-73


4. PubMed ID: 14691248
   Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
   "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
   "Proc Natl Acad Sci U S A (2004) 101:360-365