Accession
MI0000825
Symbol
HGNC:
MIR345
Description
Homo sapiens
hsa-mir-345 precursor miRNA mir-345
Gene
family?
family?
RF01044;
mir-345
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR345 is a methylation-sensitive microRNA (miRNA) that is involved in cell proliferation and invasion in colorectal cancer [PMC3383700]. It has been found to be differentially expressed in pancreatic cancer tissues, suggesting its potential as a therapeutic target for pancreatic malignancy [PMC7457762]. MIR345 has also been identified as one of the miRNAs expressed at low levels in tumor tissues or cells [PMC7797122]. Additionally, its expression has been reported to reduce dose-dependently in the model of endothelial injury induced by oxLDL [PMC9199460]. The aberrant expression of MIR345, along with other miRNAs such as let-7, miR-34, and miR-342, is regulated by DNA methylation and is associated with the development of colorectal cancer [PMC9141994] [PMC8910953]. In the context of gastric cancer (GC), MIR345 has been identified as one of the factors related to survival [PMC5856436]. Furthermore, MIR345 has been identified as a metastasis-suppressive gene in colorectal cancer along with other protein-coding genes and microRNAs [PMC8484294]. In leukoplakia and invasive oral squamous cell carcinoma (OSCC), overexpression of MIR345 has been associated with increases in lesion severity during progression, suggesting its potential role in malignant transformation [PMC3292026] [PMC5596676]. Overall, MIR345 is a methylation-sensitive miRNA that plays important roles in various cancers and may serve as a potential therapeutic target or prognostic marker.
Literature search
39 open access papers mention hsa-mir-345
(137 sentences)
(137 sentences)
Sequence
30865
reads,
321
reads per million, 125 experiments
acccaaacccuaggucuGCUGACUCCUAGUCCAGGGCUCgugauggcugguggGCCCUGAACGAGGGGUCUGGAGgccuggguuugaauaucgacagc
...(((((((.((((((.(.(((((((.((.((((((((((........)))))))))).)).))))))).).)))))))))))))............
...(((((((.((((((.(.(((((((.((.((((((((((........)))))))))).)).))))))).).)))))))))))))............
Structure
---------acc u G U A C gau
caaaccc aggucu C GACUCCU GU CAGGGCUCgu g
||||||| |||||| | ||||||| || ||||||||||
guuuggg uccgGA G CUGGGGA CA GUCCCGggug g
cgacagcuauaa - G U G A guc
Annotation confidence
High
Do you think this miRNA is real?
Comments
This sequence is the predicted human homologue [2] of a sequence cloned from rat neuronal tissue [1], later validated in human [3,4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4]. The 5' end of the miRNA may be offset with respect to previous annotations.
Genome context
chr14: 100307859-100307956 [+]
Disease association
hsa-mir-345 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-345-5p
| Accession | MIMAT0000772 |
| Description | Homo sapiens hsa-miR-345-5p mature miRNA |
| Sequence | 18 - GCUGACUCCUAGUCCAGGGCUC - 39 |
| Evidence |
experimental
cloned [3-4], Northern [3] |
| Database links |
|
| Predicted targets |
|
Mature hsa-miR-345-3p
| Accession | MIMAT0022698 |
| Description | Homo sapiens hsa-miR-345-3p mature miRNA |
| Sequence | 54 - GCCCUGAACGAGGGGUCUGGAG - 75 |
| Evidence | not_experimental |
| Database links |
|
| Predicted targets |
|
References
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