miRBase entry: hsa-mir-345

Stem-loop hsa-mir-345

Homo sapiens hsa-mir-345 precursor miRNA
Gene family
MIPF0000189; mir-345

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR345 is a methylation-sensitive microRNA (miRNA) that is involved in cell proliferation and invasion in colorectal cancer [PMC3383700]. It has been found to be differentially expressed in pancreatic cancer tissues, suggesting its potential as a therapeutic target for pancreatic malignancy [PMC7457762]. MIR345 has also been identified as one of the miRNAs expressed at low levels in tumor tissues or cells [PMC7797122]. Additionally, its expression has been reported to reduce dose-dependently in the model of endothelial injury induced by oxLDL [PMC9199460]. The aberrant expression of MIR345, along with other miRNAs such as let-7, miR-34, and miR-342, is regulated by DNA methylation and is associated with the development of colorectal cancer [PMC9141994] [PMC8910953]. In the context of gastric cancer (GC), MIR345 has been identified as one of the factors related to survival [PMC5856436]. Furthermore, MIR345 has been identified as a metastasis-suppressive gene in colorectal cancer along with other protein-coding genes and microRNAs [PMC8484294]. In leukoplakia and invasive oral squamous cell carcinoma (OSCC), overexpression of MIR345 has been associated with increases in lesion severity during progression, suggesting its potential role in malignant transformation [PMC3292026] [PMC5596676]. Overall, MIR345 is a methylation-sensitive miRNA that plays important roles in various cancers and may serve as a potential therapeutic target or prognostic marker.

Literature search
39 open access papers mention hsa-mir-345
(137 sentences)


30865 reads, 321 reads per million, 125 experiments

---------acc       u      G U       A  C          gau 
            caaaccc aggucu C GACUCCU GU CAGGGCUCgu   g
            ||||||| |||||| | ||||||| || ||||||||||    
            guuuggg uccgGA G CUGGGGA CA GUCCCGggug   g
cgacagcuauaa       -      G U       G  A          guc 

Annotation confidence High
Do you think this miRNA is real?
This sequence is the predicted human homologue [2] of a sequence cloned from rat neuronal tissue [1], later validated in human [3,4]. The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies [4]. The 5' end of the miRNA may be offset with respect to previous annotations.

Genome context
chr14: 100307859-100307956 [+]

Disease association
hsa-mir-345 is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Database links

Mature hsa-miR-345-5p

Accession MIMAT0000772
Description Homo sapiens hsa-miR-345-5p mature miRNA
Evidence experimental
cloned [3-4], Northern [3]
Database links
Predicted targets

Mature hsa-miR-345-3p

Accession MIMAT0022698
Description Homo sapiens hsa-miR-345-3p mature miRNA
Evidence not_experimental
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15978578
    Identification of human fetal liver miRNAs by a novel method
    "Fu H, Tie Y, Xu C, Zhang Z, Zhu J, Shi Y, Jiang H, Sun Z, Zheng X"
    "FEBS Lett (2005) 579:3849-3854

  3. PubMed ID: 15634332
    New human and mouse microRNA genes found by homology search
    "Weber MJ"
    "FEBS J (2005) 272:59-73

  4. PubMed ID: 14691248
    Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
    "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
    "Proc Natl Acad Sci U S A (2004) 101:360-365