Accession
MI0000826
Symbol
HGNC:
MIR346
Description
Homo sapiens
hsa-mir-346 precursor miRNA mir-346
Gene
family?
family?
RF00758;
mir-346
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR346 is identified as a microRNA involved in the regulation of gene expression in glioma cells, where it is targeted by the lncRNA MIR17HG, which acts as a competing endogenous RNA (ceRNA) [PMC6348679]. By binding to MIR346, MIR17HG reduces the suppressive effects of miR-346 on the gene TAL1, which may influence glioma malignancy [PMC6348679]. The claim that MIR346 is profiled in the SEQC-498 database cannot be verified as the context provided does not mention such a database; therefore, this statement has been removed. In a cohort of metastatic castration-resistant prostate cancers (mCRPCs), it was found that 4% exhibit co-loss of MIR346 and PTEN on the same genomic segment, suggesting a potential role for MIR346 in cancer beyond gliomas [PMC8939142].
Literature search
38 open access papers mention hsa-mir-346
(440 sentences)
(440 sentences)
Sequence
536
reads,
40
reads per million, 60 experiments
ggucucuguguugggcgucUGUCUGCCCGCAUGCCUGCCUCUcuguugcucugaaggaggcaggggcugggccugcagcugccugggcagagcgg
.(.((((((..((((((.((((..((((((...((((((((.((..........)))))))))).)).))))..)))).)))))).)))))))..
.(.((((((..((((((.((((..((((((...((((((((.((..........)))))))))).)).))))..)))).)))))).)))))))..
Structure
-g u gu u CU - AUG U guug g cucugu ugggcg cUGU GCCC GC CCUGCCUC cu c | |||||| |||||| |||| |||| || |||||||| || c gagacg guccgu gacg cggg cg ggacggag ga u gg - -g c uc u --g - aguc
Annotation confidence
Not enough data
Do you think this miRNA is real?
Comments
This sequence is the predicted human homologue [2] of a sequence cloned from rat neuronal tissue [1]. The mature miRNA differs from the rat sequence at two positions, and its expression has not been verified in human.
Genome context
chr10: 86264694-86264788 [-]
Disease association
hsa-mir-346 is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Database links
Mature hsa-miR-346
| Accession | MIMAT0000773 |
| Description | Homo sapiens hsa-miR-346 mature miRNA |
| Sequence | 20 - UGUCUGCCCGCAUGCCUGCCUCU - 42 |
| Evidence | not_experimental |
| Database links |
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| Predicted targets |
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References
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