miRBase entry: rno-let-7b

Stem-loop rno-let-7b


Accession
MI0000829
Description
Rattus norvegicus rno-let-7b precursor miRNA

Literature search
108 open access papers mention rno-let-7b
(736 sentences)

Sequence

1298668 reads, 1369 reads per million, 506 experiments
gcggggUGAGGUAGUAGGUUGUGUGGUUucagggcagugaugucgccccuccgaagauaaCUAUACAACCUACUGCCUUCCCuga
.(((((.(((((((((((((((((((((((((((..(((....))))))).....)).)))))))))))))))))))))))))).

Structure
g     U                     -  -----    ca   a 
 cgggg GAGGUAGUAGGUUGUGUGGUU uc     aggg  gug u
 ||||| ||||||||||||||||||||| ||     ||||  |||  
 guCCC UUCCGUCAUCCAACAUAUCaa ag     uccc  cgc g
a     -                     u  aagcc    --   u 


Annotation confidence High
Do you think this miRNA is real?

Genome context
chr7: 126590627-126590711 [+]
Clustered miRNAs
1 other miRNA is < 10 kb from rno-let-7b
Name Accession Chromosome Start End Strand Confidence




Database links

Mature rno-let-7b-5p

Accession MIMAT0000775
Description Rattus norvegicus rno-let-7b-5p mature miRNA
Sequence 7 - UGAGGUAGUAGGUUGUGUGGUU - 28
Evidence experimental
cloned [1-4], SOLiD [5]

Mature rno-let-7b-3p

Accession MIMAT0004705
Description Rattus norvegicus rno-let-7b-3p mature miRNA
Sequence 61 - CUAUACAACCUACUGCCUUCCC - 82
Evidence experimental
cloned [4], SOLiD [5]

References

  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 16766679
    Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testes
    "Watanabe T, Takeda A, Tsukiyama T, Mise K, Okuno T, Sasaki H, Minami N, Imai H"
    "Genes Dev (2006) 20:1732-1743

  3. PubMed ID: 14691248
    Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
    "Kim J, Krichevsky A, Grad Y, Hayes GD, Kosik KS, Church GM, Ruvkun G"
    "Proc Natl Acad Sci U S A (2004) 101:360-365

  4. PubMed ID: 20403161
    Small RNA expression and strain specificity in the rat
    Linsen SE, de Wit E, de Bruijn E, Cuppen E
    BMC Genomics (2010) 11:249

  5. PubMed ID: 15345052
    Microarray analysis of microRNA expression in the developing mammalian brain
    Miska EA, Alvarez-Saavedra E, Townsend M, Yoshii A, Sestan N, Rakic P, Constantine-Paton M, Horvitz HR
    Genome Biol (2004) 5:R68