Accession
MI0001648
Symbol
HGNC:
MIR449A
Description
Homo sapiens
hsa-mir-449a precursor miRNA mir-449
Gene
family?
family?
RF00711;
mir-449
Summary
Caution, this is an AI generated summary based on literature. This may have errors. ?
MIR449A is identified as an endogenous regulator of MET-mediated epithelial-mesenchymal transition (EMT), alongside other regulators such as miR-148a and SENP1 [PMC5643285]. This small RNA is also implicated in the cellular response to hypoxia/reoxygenation (H/R) injury in H9C2 cells, with studies suggesting a functional link between MIR449A and the nuclear receptor subfamily 4 group A member 2 (NR4A2) [PMC8406901]. Additionally, MIR449A is listed among the genes encoding small RNAs in Emca3, which also includes miR449c and miR582 [PMC4132170].
Literature search
129 open access papers mention hsa-mir-449a
(1256 sentences)
(1256 sentences)
Sequence
3957
reads,
127
reads per million, 73 experiments
cugugugugaugagcUGGCAGUGUAUUGUUAGCUGGUugaauaugugaauggcaucggcuaacaugcaacugcugucuuauugcauauaca
.(((((((((((((.(((((((((((.((((((((((.(..(((....))).))))))))))))))).))))))).)))))))))))))..
.(((((((((((((.(((((((((((.((((((((((.(..(((....))).))))))))))))))).))))))).)))))))))))))..
Structure
-c c - U u aa g ugugugugaugag UGGCAGU GUAU GUUAGCUGGU g uau u ||||||||||||| ||||||| |||| |||||||||| | ||| auauacguuauuc gucguca cgua caaucggcua c gua g ac u a - - -g a
Annotation confidence
Not enough data
Do you think this miRNA is real?
Comments
Xie et al. [1] refer to this sequence by the internal identifier MIR54. The sequence is unrelated to C. elegans mir-54 (MIR:MI0000025).
Genome context
chr5: 55170532-55170622 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-449a
| Name | Accession | Chromosome | Start | End | Strand | Confidence |
|---|
Disease association
hsa-mir-449a is associated with one or more human diseases in the Human microRNA Disease Database
| Disease | Description | Category | PubMed ID |
|---|
Biological pathways
hsa-mir-449a is involved in one or more biological pathways:
(Source: Reactome)
(Source: Reactome)
Biological reactions
hsa-mir-449a is involved in one or more regulation/signalling events:
(Source: Reactome)
(Source: Reactome)
Database links
Mature hsa-miR-449a
| Accession | MIMAT0001541 |
| Description | Homo sapiens hsa-miR-449a mature miRNA |
| Sequence | 16 - UGGCAGUGUAUUGUUAGCUGGU - 37 |
| Evidence |
experimental
cloned [1-2] |
| Database links |
|
| Predicted targets |
|
References
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