Stem-loop hsa-mir-449a

Accession

MI0001648

Symbol

HGNC: MIR449A

Description

Homo sapiens hsa-mir-449a precursor miRNA mir-449

Gene
family

RF00711; mir-449

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR449A is a type of endogenous regulator of MET-mediated EMT, along with miR-148a and SENP1 [PMC5643285]. It has been found to play a role in H9C2 cell damage caused by H/R, and its functional association with NR4A2 has been investigated [PMC8406901]. These findings highlight the importance of MIR449A in regulating cellular processes and its potential role in various biological contexts [PMC5643285][PMC8406901[PMC8406901].

Literature search

129 open access papers mention hsa-mir-449a
(1256 sentences)

Sequence

3957 reads, 127 reads per million, 73 experiments

cugugugugaugagcUGGCAGUGUAUUGUUAGCUGGUugaauaugugaauggcaucggcuaacaugcaacugcugucuuauugcauauaca
.(((((((((((((.(((((((((((.((((((((((.(..(((....))).))))))))))))))).))))))).)))))))))))))..

Structure

-c             c       -    U          u aa   g 
  ugugugugaugag UGGCAGU GUAU GUUAGCUGGU g  uau u
  ||||||||||||| ||||||| |||| |||||||||| |  |||  
  auauacguuauuc gucguca cgua caaucggcua c  gua g
ac             u       a    -          - -g   a 

Annotation confidence Not enough data

Comments

Xie et al. [1] refer to this sequence by the internal identifier MIR54. The sequence is unrelated to C. elegans mir-54 (MIR:MI0000025).

Genome context

chr5: 55170532-55170622 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-449a

Disease association

hsa-mir-449a is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-449a is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-449a is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-449a

• Accession: MIMAT0001541
• Description: Homo sapiens hsa-miR-449a mature miRNA
• Sequence: 16 - UGGCAGUGUAUUGUUAGCUGGU - 37
• Evidence: experimental ; cloned [1-2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15735639
   Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
   "Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M"
   "Nature (2005) 434:338-345