Stem-loop hsa-mir-449a

Accession

MI0001648

Symbol

HGNC: MIR449A

Description

Homo sapiens hsa-mir-449a precursor miRNA mir-449

Gene
family

RF00711; mir-449

Summary

Caution, this is an AI generated summary based on literature. This may have errors.

MIR449A is identified as an endogenous regulator of MET-mediated epithelial-mesenchymal transition (EMT), alongside other regulators such as miR-148a and SENP1 [PMC5643285]. This small RNA is also implicated in the cellular response to hypoxia/reoxygenation (H/R) injury in H9C2 cells, with studies suggesting a functional link between MIR449A and the nuclear receptor subfamily 4 group A member 2 (NR4A2) [PMC8406901]. Additionally, MIR449A is listed among the genes encoding small RNAs in Emca3, which also includes miR449c and miR582 [PMC4132170].

Literature search

129 open access papers mention hsa-mir-449a
(1256 sentences)

Sequence

3955 reads, 36 reads per million, 72 experiments

cugugugugaugagcUGGCAGUGUAUUGUUAGCUGGUugaauaugugaauggcaucggcuaacaugcaacugcugucuuauugcauauaca
.(((((((((((((.(((((((((((.((((((((((.(..(((....))).))))))))))))))).))))))).)))))))))))))..

Structure

-c             c       -    U          u aa   g 
  ugugugugaugag UGGCAGU GUAU GUUAGCUGGU g  uau u
  ||||||||||||| ||||||| |||| |||||||||| |  |||  
  auauacguuauuc gucguca cgua caaucggcua c  gua g
ac             u       a    -          - -g   a 

Annotation confidence Low

Comments

Xie et al. [1] refer to this sequence by the internal identifier MIR54. The sequence is unrelated to C. elegans mir-54 (MIR:MI0000025).

Genome context

chr5: 55170532-55170622 [-]

Clustered miRNAs

2 other miRNAs are < 10 kb from hsa-mir-449a

Disease association

hsa-mir-449a is associated with one or more human diseases in the Human microRNA Disease Database

Biological pathways

hsa-mir-449a is involved in one or more biological pathways:

(Source: Reactome)

Biological reactions

hsa-mir-449a is involved in one or more regulation/signalling events:

(Source: Reactome)

Mature hsa-miR-449a

• Accession: MIMAT0001541
• Description: Homo sapiens hsa-miR-449a mature miRNA
• Sequence: 16 - UGGCAGUGUAUUGUUAGCUGGU - 37
• Evidence: experimental ; cloned [1-2]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 15735639
   Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
   "Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M"
   "Nature (2005) 434:338-345