miRBase entry: hsa-mir-449a

Stem-loop hsa-mir-449a

Homo sapiens hsa-mir-449a precursor miRNA
Gene family
MIPF0000133; mir-449

Caution, this is an AI generated summary based on literature. This may have errors. ?

MIR449A is a type of endogenous regulator of MET-mediated EMT, along with miR-148a and SENP1 [PMC5643285]. It has been found to play a role in H9C2 cell damage caused by H/R, and its functional association with NR4A2 has been investigated [PMC8406901]. These findings highlight the importance of MIR449A in regulating cellular processes and its potential role in various biological contexts [PMC5643285][PMC8406901[PMC8406901].

Literature search
129 open access papers mention hsa-mir-449a
(1256 sentences)


3957 reads, 127 reads per million, 73 experiments

-c             c       -    U          u aa   g 
  ugugugugaugag UGGCAGU GUAU GUUAGCUGGU g  uau u
  ||||||||||||| ||||||| |||| |||||||||| |  |||  
  auauacguuauuc gucguca cgua caaucggcua c  gua g
ac             u       a    -          - -g   a 

Annotation confidence Not enough data
Do you think this miRNA is real?
Xie et al. [1] refer to this sequence by the internal identifier MIR54. The sequence is unrelated to C. elegans mir-54 (MIR:MI0000025).

Genome context
chr5: 55170532-55170622 [-]
Clustered miRNAs
2 other miRNAs are < 10 kb from hsa-mir-449a
Name Accession Chromosome Start End Strand Confidence

Disease association
hsa-mir-449a is associated with one or more human diseases in the Human microRNA Disease Database
Disease Description Category PubMed ID

Biological pathways
hsa-mir-449a is involved in one or more biological pathways:
(Source: Reactome)
Biological reactions
hsa-mir-449a is involved in one or more regulation/signalling events:
(Source: Reactome)

Database links

Mature hsa-miR-449a

Accession MIMAT0001541
Description Homo sapiens hsa-miR-449a mature miRNA
Evidence experimental
cloned [1-2]
Database links
Predicted targets


  1. PubMed ID: 17604727
    A mammalian microRNA expression atlas based on small RNA library sequencing
    "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
    "Cell (2007) 129:1401-1414

  2. PubMed ID: 15735639
    Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
    "Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M"
    "Nature (2005) 434:338-345