Stem-loop mmu-mir-449a

Accession

MI0001649

Symbol

MGI: Mir449a

Description

Mus musculus mmu-mir-449a precursor miRNA mir-449

Gene
family

RF00711; mir-449

Literature search

72 open access papers mention mmu-mir-449a
(825 sentences)

Sequence

37383 reads, 1105 reads per million, 88 experiments

cugugugugauggcuUGGCAGUGUAUUGUUAGCUGGUugaguaugugagcggcacCAGCUAACAUGCGACUGCUCUCcuauugcacacaca
.((((((((((((...((((((((((.((((((((((...((......))...)))))))))))))).))))))...))))))))))))..

Structure

-c            cuU      -    U          uga  au 
  ugugugugaugg   GGCAGU GUAU GUUAGCUGGU   gu  g
  ||||||||||||   |||||| |||| ||||||||||   ||   
  acacacguuauc   UCGUCA CGUA CAAUCGACca   cg  u
ac            CUC      G    -          cgg  ag 

Annotation confidence Medium

Comments

Xie et al. [1] refer to this sequence by the internal identifier MIR54. The sequence is unrelated to C. elegans mir-54 (MIR:MI0000025).

Genome context

chr13: 113037534-113037624 [+]

Clustered miRNAs

2 other miRNAs are < 10 kb from mmu-mir-449a

Mature mmu-miR-449a-5p

• Accession: MIMAT0001542
• Description: Mus musculus mmu-miR-449a-5p mature miRNA
• Sequence: 16 - UGGCAGUGUAUUGUUAGCUGGU - 37
• Evidence: experimental ; cloned [2], Illumina [3-4]

Mature mmu-miR-449a-3p

• Accession: MIMAT0017180
• Description: Mus musculus mmu-miR-449a-3p mature miRNA
• Sequence: 56 - CAGCUAACAUGCGACUGCUCUC - 77
• Evidence: experimental ; Illumina [4]

References

1. PubMed ID: 17604727
   A mammalian microRNA expression atlas based on small RNA library sequencing
   "Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, Aravin A, Pfeffer S, Rice A, Kamphorst AO, Landthaler M, Lin C, Socci ND, Hermida L, Fulci V, Chiaretti S, Foa R, Schliwka J, Fuchs U, Novosel A, Muller RU, Schermer B, Bissels U, Inman J, Phan Q, Chien M"
   "Cell (2007) 129:1401-1414


2. PubMed ID: 20215419
   MicroRNA transcriptome in the newborn mouse ovaries determined by massive parallel sequencing
   "Ahn HW, Morin RD, Zhao H, Harris RA, Coarfa C, Chen ZJ, Milosavljevic A, Marra MA, Rajkovic A"
   "Mol Hum Reprod (2010) 16:463-471


3. PubMed ID: 20413612
   Mammalian microRNAs: experimental evaluation of novel and previously annotated genes
   "Chiang HR, Schoenfeld LW, Ruby JG, Auyeung VC, Spies N, Baek D, Johnston WK, Russ C, Luo S, Babiarz JE, Blelloch R, Schroth GP, Nusbaum C, Bartel DP"
   "Genes Dev (2010) 24:992-1009


4. PubMed ID: 15735639
   Systematic discovery of regulatory motifs in human promoters and 3' UTRs by comparison of several mammals
   "Xie X, Lu J, Kulbokas EJ, Golub TR, Mootha V, Lindblad-Toh K, Lander ES, Kellis M"
   "Nature (2005) 434:338-345